Labia Majora Rejuvenation With Hybrid Filler: A Narrative Review of the Literature and Report of Two Cases

IF 2.3 4区医学 Q2 DERMATOLOGY Journal of Cosmetic Dermatology Pub Date : 2025-02-27 DOI:10.1111/jocd.70074

Andrea Acevedo, Andrea Marcela Parra, Andreina Martinez Amado, Valentina Dicker, Desiree Castelanich, Lina Velasquez, Luis Alberto Parra

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Abstract

Background

Esthetic gynecology addresses the growing demand for treatments covering functional and esthetic concerns of the external genitalia, significantly impacting women's confidence and sexual relationships. While hyaluronic acid (HA) and calcium hydroxylapatite (CaHA) have shown promise in vaginal rejuvenation, data on hybrid filler applications remain limited.

Objective

This narrative review examines the anatomical, structural, and psychological aspects of labia majora rejuvenation, outlining available treatment options and presenting the authors' experience with a novel HA/CaHA hybrid filler.

Methods

This paper combined a narrative literature review using online databases PubMed and Google Scholar, between 2015 and 2024, with the keywords: “labia majora,” “rejuvenation,” “aesthetic treatments,” and “fillers” with a case series of two patients treated with a hybrid CaHA/HA (Radiesse and Belotero Balance Merz Pharmaceuticals GmbH) filler for labia majora volume loss and laxity.

Results

Sixty-day follow-up evaluations by four experienced physicians revealed substantial improvements in labia majora esthetics. A marked improvement in skin coloration was observed in both patients, with skin appearing more even and less hyperpigmented. Both patients showed noticeable volume restoration, resulting in a fuller appearance of the labia majora. Overall aesthetic improvement was evident, as confirmed by the patients' perception. Patient-reported genital appearance satisfaction, as measured by the GAS score, improved by a mean of 41% (pretreatment mean: 28/33; posttreatment mean: 15/33).

Conclusion

These two case reports and a narrative literature review suggest that a combined HA/CaHA filler may be a safe and effective treatment for labia majora rejuvenation.

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来源期刊

Journal of Cosmetic Dermatology DERMATOLOGY-

CiteScore

4.30

自引率

13.00%

发文量

818

审稿时长

>12 weeks

期刊介绍： The Journal of Cosmetic Dermatology publishes high quality, peer-reviewed articles on all aspects of cosmetic dermatology with the aim to foster the highest standards of patient care in cosmetic dermatology. Published quarterly, the Journal of Cosmetic Dermatology facilitates continuing professional development and provides a forum for the exchange of scientific research and innovative techniques. The scope of coverage includes, but will not be limited to: healthy skin; skin maintenance; ageing skin; photodamage and photoprotection; rejuvenation; biochemistry, endocrinology and neuroimmunology of healthy skin; imaging; skin measurement; quality of life; skin types; sensitive skin; rosacea and acne; sebum; sweat; fat; phlebology; hair conservation, restoration and removal; nails and nail surgery; pigment; psychological and medicolegal issues; retinoids; cosmetic chemistry; dermopharmacy; cosmeceuticals; toiletries; striae; cellulite; cosmetic dermatological surgery; blepharoplasty; liposuction; surgical complications; botulinum; fillers, peels and dermabrasion; local and tumescent anaesthesia; electrosurgery; lasers, including laser physics, laser research and safety, vascular lasers, pigment lasers, hair removal lasers, tattoo removal lasers, resurfacing lasers, dermal remodelling lasers and laser complications.