Oxidative Score and Microvesicle Profile Suggest Cardiovascular Risk in Chronic Kidney Disease.

IF 6 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Antioxidants Pub Date : 2025-02-03 DOI:10.3390/antiox14020178

Gemma Valera-Arévalo, María Del Mar Rodríguez-San Pedro, Paula Jara Caro, Víctor Cabanillas, María Gabriela Ortiz-Diaz, Andrea Figuer, Claudia Yuste, Rafael Ramírez, Matilde Alique, Enrique Morales, Natalia Guerra-Pérez, Julia Carracedo

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Abstract

Chronic kidney disease (CKD) is associated with a high incidence of cardiovascular disease (CVD) due to the accumulation of uremic toxins, altered redox state, and chronic systemic inflammation. This study aimed to analyze the relationship between the redox status of patients with CKD and the phenotype of microvesicles (MVs) subtypes, and cardiovascular events. The oxidative stress level of each participant was determined using an individualized OXY-SCORE. The relationship between pro-oxidant and antioxidant parameters and the expression of membrane markers in endothelial-derived microvesicles (EMVs) and platelet-derived microvesicles (PMVs) was established. Patients with advanced CKD (ACKD) and hemodialysis (HD) had a higher OXY-SCORE than healthy subjects (HS), whereas peritoneal dialysis (PD) patients had similar scores to HS. PD patients showed elevated PMVs and CD41 expression, whereas HD patients had higher EMVs and CD31 expression. Patients with ACKD had higher tissue factor (TF) expression in the PMVs and EMVs. TF expression was correlated with xanthine oxidase (XO) activity and was negatively correlated with antioxidant parameters. Patients with cardiovascular events show elevated TF. In conclusion, microvesicles and oxidative stress may serve as markers of cardiovascular risk in CKD, with TF expression in PMVs and EMVs being potential predictive and prognostic biomarkers of CVD.

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慢性肾脏病（CKD）与心血管疾病（CVD）的高发病率有关，这是由于尿毒症毒素的积累、氧化还原状态的改变以及慢性全身炎症所致。本研究旨在分析慢性肾脏病患者的氧化还原状态和微囊泡（MVs）亚型表型与心血管事件之间的关系。使用个体化 OXY-SCORE 测定了每位参与者的氧化应激水平。确定了促氧化和抗氧化参数与内皮源性微囊泡（EMVs）和血小板源性微囊泡（PMVs）中膜标记物表达之间的关系。晚期慢性肾脏病（ACKD）和血液透析（HD）患者的 OXY-SCORE 比健康人（HS）高，而腹膜透析（PD）患者的得分与健康人相似。腹膜透析患者的 PMVs 和 CD41 表达升高，而 HD 患者的 EMVs 和 CD31 表达升高。ACKD 患者的 PMV 和 EMV 中组织因子 (TF) 表达较高。TF表达与黄嘌呤氧化酶（XO）活性相关，与抗氧化参数呈负相关。心血管事件患者的 TF 值升高。总之，微囊泡和氧化应激可作为慢性肾脏病患者心血管风险的标志物，其中 PMVs 和 EMVs 中的 TF 表达是心血管疾病的潜在预测和预后生物标志物。

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来源期刊

Antioxidants Biochemistry, Genetics and Molecular Biology-Physiology

CiteScore

10.60

自引率

11.40%

发文量

2123

审稿时长

16.3 days

期刊介绍： Antioxidants (ISSN 2076-3921), provides an advanced forum for studies related to the science and technology of antioxidants. It publishes research papers, reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.