Mustafa Soner Özcan, Halil Aşcı, Pınar Karabacak, Eyyüp Sabri Özden, Rümeysa Taner, Özlem Özmen, Muhammet Yusuf Tepebaşı, Selçuk Çömlekçi
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Abstract
Background: Pressure injuries are still an important health problem worldwide, although many therapies have been applied to date. This study aimed to determine the optimal duration of external application of a 10 kV/m direct current (DC, static) electric field in a pressure injury model in rats. Methods: Twelve male Wistar-Albino rats were divided into three groups: Grade-1, Grade-2, and Grade-3. Two round magnets were placed 4 h daily for one day in Grade-1, two days in Grade-2, and three days in Grade-3. Following wound formation, one rat from each group was designated the control, while the other rats were exposed to a 10 kV/m electric field for 15, 30, or 60 min. Results: Histopathological improvements were observed after 15 and 30 min of application, whereas a sharp decrease in the gene expression of growth factors at 30 min revealed that 15 min of application was optimal overall. Conclusions: According to the results of this study, 15 min applications of an external 10 kV/m electric field are promising for providing satisfactory results in wound healing. Further studies should examine in greater detail the effects of electric fields on growth factors and the mechanisms underlying these responses.
期刊介绍：
Aims
Bioengineering (ISSN 2306-5354) provides an advanced forum for the science and technology of bioengineering. It publishes original research papers, comprehensive reviews, communications and case reports. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. All aspects of bioengineering are welcomed from theoretical concepts to education and applications. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. There are, in addition, four key features of this Journal:
● We are introducing a new concept in scientific and technical publications “The Translational Case Report in Bioengineering”. It is a descriptive explanatory analysis of a transformative or translational event. Understanding that the goal of bioengineering scholarship is to advance towards a transformative or clinical solution to an identified transformative/clinical need, the translational case report is used to explore causation in order to find underlying principles that may guide other similar transformative/translational undertakings.
● Manuscripts regarding research proposals and research ideas will be particularly welcomed.
● Electronic files and software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.
● We also accept manuscripts communicating to a broader audience with regard to research projects financed with public funds.
Scope
● Bionics and biological cybernetics: implantology; bio–abio interfaces
● Bioelectronics: wearable electronics; implantable electronics; “more than Moore” electronics; bioelectronics devices
● Bioprocess and biosystems engineering and applications: bioprocess design; biocatalysis; bioseparation and bioreactors; bioinformatics; bioenergy; etc.
● Biomolecular, cellular and tissue engineering and applications: tissue engineering; chromosome engineering; embryo engineering; cellular, molecular and synthetic biology; metabolic engineering; bio-nanotechnology; micro/nano technologies; genetic engineering; transgenic technology
● Biomedical engineering and applications: biomechatronics; biomedical electronics; biomechanics; biomaterials; biomimetics; biomedical diagnostics; biomedical therapy; biomedical devices; sensors and circuits; biomedical imaging and medical information systems; implants and regenerative medicine; neurotechnology; clinical engineering; rehabilitation engineering
● Biochemical engineering and applications: metabolic pathway engineering; modeling and simulation
● Translational bioengineering
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