Flavonoids serve as a promising therapeutic agent for ischemic stroke.

IF 2.7 4区医学 Q3 NEUROSCIENCES Brain Research Pub Date : 2025-02-23 DOI:10.1016/j.brainres.2025.149528

Hongxin Shu, Qiuye Liao, Zhihao Chen, Mingyu Liang, Si Zhang, Junzhe Liu, Yanze Wu, Ping Hu, Ming Luo, Wenping Zhu, Xingen Zhu, Li Yang, Tengfeng Yan

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Abstract

Ischemic stroke (IS) continues to be a major public health concern and is characterized by significantly high mortality and disabling rates. Inhibiting nerve cells death and enhancing the repair of ischemic tissue are important treatment concepts for IS. Currently, the mainstream treatment strategies mainly focus on short-term care, which underscores the urgent need for novel therapeutic strategies for long-term care. Emerging data reveal that flavonoids have surfaced as promising candidates for IS patients' long-term care. Flavonoids can alleviate neuroinflammation and anti-apoptosis due to their characteristic pharmacological mechanisms. Clinical evidence suggests that long-term flavonoids intake improves IS patients' long-term outcomes. Though the effect of flavonoids in IS treatment has been explored for decades, the neuroprotective pharmacodynamics have not been well established. Thereby, the aim of current review is to summarize the pathways involved in neuroprotective effect of flavonoids. This review will also advance the potential of flavonoids as a viable clinical candidate for the treatment of IS.

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缺血性脑卒中（IS）仍然是一个重大的公共卫生问题，其特点是死亡率和致残率极高。抑制神经细胞死亡和促进缺血组织修复是治疗缺血性中风的重要理念。目前，主流的治疗策略主要集中在短期治疗上，这凸显了对长期治疗的新型治疗策略的迫切需求。新的数据显示，类黄酮已成为IS患者长期护理的有望候选药物。类黄酮具有独特的药理机制，可以缓解神经炎症和抗凋亡。临床证据表明，长期摄入类黄酮可改善IS患者的长期预后。虽然黄酮类化合物在IS治疗中的作用已被探索了数十年，但其神经保护药效学尚未得到很好的证实。因此，本综述旨在总结黄酮类化合物的神经保护作用所涉及的途径。本综述还将推动黄酮类化合物作为治疗 IS 的可行临床候选药物的潜力。

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来源期刊

Brain Research 医学-神经科学

CiteScore

5.90

自引率

3.40%

发文量

268

审稿时长

47 days

期刊介绍： An international multidisciplinary journal devoted to fundamental research in the brain sciences. Brain Research publishes papers reporting interdisciplinary investigations of nervous system structure and function that are of general interest to the international community of neuroscientists. As is evident from the journals name, its scope is broad, ranging from cellular and molecular studies through systems neuroscience, cognition and disease. Invited reviews are also published; suggestions for and inquiries about potential reviews are welcomed. With the appearance of the final issue of the 2011 subscription, Vol. 67/1-2 (24 June 2011), Brain Research Reviews has ceased publication as a distinct journal separate from Brain Research. Review articles accepted for Brain Research are now published in that journal.