Association Between Body Mass Index and Glycemic Control in Type 2 Diabetes Mellitus: A Cross-Sectional Study.

IF 3 3区医学 Q3 ENDOCRINOLOGY & METABOLISM Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pub Date : 2025-02-21 eCollection Date: 2025-01-01 DOI:10.2147/DMSO.S508365

Li Deng, Long Jia, Xiao-Li Wu, Ming Cheng

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Abstract

Background: Body mass index (BMI) is a known risk factor for poor glycemic control in patients with Type 2 diabetes mellitus (T2DM). However, the extent to which BMI correlates with glycated hemoglobin (HbA1c) levels and its clinical implications require further investigation.

Objective: This study aimed to assess the relationship between BMI and HbA1c levels in T2DM patients and to explore the clinical significance of BMI management in optimizing glycemic control.

Methods: A cross-sectional study was conducted on 200 T2DM patients from Jinniu District Hospital between 2024/04/01 and 2024/10/03. BMI and HbA1c levels were recorded, and patients were categorized into normal weight (BMI < 25 kg/m²), overweight (25 ≤ BMI < 30 kg/m²), and obese (BMI ≥ 30 kg/m²). Pearson correlation analysis was used to assess the relationship between BMI and HbA1c. One-way ANOVA was employed to compare HbA1c levels across BMI categories.

Results: A significant positive correlation between BMI and HbA1c was observed (r = 0.45, P < 0.001). Obese patients had significantly higher HbA1c levels (8.5 [7.8-9.0]%) compared to overweight (7.7 [7.2-8.1]%, P < 0.01) and normal-weight patients (6.9 [6.4-7.5]%, P < 0.001). The graded relationship indicated worsening glycemic control with increasing BMI.

Conclusion: Higher BMI is associated with poorer glycemic control in T2DM patients. Obese patients, in particular, may benefit from more intensive weight management strategies to reduce HbA1c levels and prevent diabetes-related complications. These findings underscore the importance of integrating BMI reduction into diabetes management plans to improve clinical outcomes.

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2型糖尿病体重指数与血糖控制之间的关系：一项横断面研究

背景：体重指数（BMI）是2型糖尿病（T2DM）患者血糖控制不良的已知危险因素。然而，BMI与糖化血红蛋白（HbA1c）水平的相关程度及其临床意义有待进一步研究。目的：本研究旨在评估T2DM患者BMI与HbA1c水平的关系，探讨BMI管理对优化血糖控制的临床意义。方法：对金牛区医院2024年4月1日至2024年10月3日收治的200例T2DM患者进行横断面研究。记录BMI和HbA1c水平，并将患者分为正常体重（BMI < 25 kg/m²）、超重（25≤BMI < 30 kg/m²）和肥胖（BMI≥30 kg/m²）。采用Pearson相关分析评估BMI与HbA1c之间的关系。采用单因素方差分析比较不同BMI类别的HbA1c水平。结果：BMI与HbA1c呈显著正相关（r = 0.45, P < 0.001）。肥胖患者的HbA1c水平（8.5[7.8-9.0]%）明显高于超重患者（7.7 [7.2-8.1]%,P < 0.01）和正常体重患者（6.9 [6.4-7.5]%,P < 0.001）。分级关系表明血糖控制随着BMI的增加而恶化。结论：高BMI与T2DM患者较差的血糖控制相关。肥胖患者尤其可能受益于更强化的体重管理策略，以降低HbA1c水平并预防糖尿病相关并发症。这些发现强调了将BMI降低纳入糖尿病管理计划以改善临床结果的重要性。

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来源期刊

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

5.90

自引率

6.10%

发文量

431

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed, open access, online journal. The journal is committed to the rapid publication of the latest laboratory and clinical findings in the fields of diabetes, metabolic syndrome and obesity research. Original research, review, case reports, hypothesis formation, expert opinion and commentaries are all considered for publication.