From the first descriptions to recent advances: 115 years of reptile Plasmodium research in the Neotropics.

Abstract

Haemosporida research started in the 19th century with the description of Plasmodium and other related parasites infecting mammals and birds. Here, we highlight the pioneering contributions of Henrique Aragão and Arthur Neiva in describing the first two Plasmodium species in lizards from the New World, Plasmodium diploglossi and Plasmodium tropiduri, published in the first printed issue of Memórias do Instituto Oswaldo Cruz in April 1909. We use these discoveries as a background to explore some historical and taxonomic aspects of Plasmodium species infecting reptiles, with a particular emphasis on the advancements made over the past 115 years in the Neotropics. Our review underscores the complexities and persistent challenges in the taxonomic classification of reptile haemosporidians and discusses some scientific advances in the field that improved our understanding of the biology and evolution of these parasites.