Feasibility, reliability, and validity of ambulatory smartphone-administered cognitive tests in multiple sclerosis.

IF 4.8 2区医学 Q1 CLINICAL NEUROLOGY Multiple Sclerosis Journal Pub Date : 2025-02-25 DOI:10.1177/13524585251320814

Josiah J Goga, Keara M Ginell, Yee To Ng, Dawn M Ehde, Kevin N Alschuler, Martin J Sliwinski, Nora E Fritz, Anna L Kratz

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Abstract

Background: Detection of subtle changes in cognition in multiple sclerosis (MS) may be enabled by ambulatory smartphone-based cognitive tests.

Objective: To examine the feasibility, reliability, and validity of ambulatory cognitive tests in people with MS.

Method: Adults with MS (N = 255) completed the NIH Toolbox Cognitive Battery, Symbol Digit Modalities Test, Paced Auditory Serial Addition Test-3, and 14 days of 4X/day ambulatory cognitive tests of working memory (dot memory) and processing speed (symbol search). Feasibility (response rates), measurement reliability (overall and by number of days of tests), and construct validity (convergent validity and known-groups analyses) were calculated.

Results: Participants completed 80.1% of available testing sessions. Reliability was 0.98 for dot memory and 0.99 for symbol search. Reliability attained ⩾0.90 within 3 days for dot memory and 1 day for symbol search. Symbol search scores correlated significantly with neuropsychological tests of processing speed (rs range = |0.53-0.69|) and differed significantly by disability level (t = -3.95, p < 0.001) and MS subtype (t = -2.81, p = 0.005). Dot memory scores correlated with neuropsychological tests of working memory (rs range = |0.45-0.58|); dot memory scores did not differ by disability level or MS subtype.

Conclusion: Smartphone-administered tests of working memory and processing speed demonstrate good feasibility, reliability, and construct validity in MS.

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背景：多发性硬化症（MS）患者认知能力的细微变化可通过基于智能手机的动态认知测试进行检测：多发性硬化症（MS）患者认知能力的细微变化可通过基于智能手机的非卧床认知测试进行检测：目的：研究多发性硬化症患者的流动认知测试的可行性、可靠性和有效性：方法：成年多发性硬化症患者（255 人）完成 NIH 工具箱认知测试、符号数字模型测试、步调听觉连续加法测试-3，以及 14 天 4 次/天的工作记忆（点记忆）和处理速度（符号搜索）流动认知测试。计算了可行性（应答率）、测量可靠性（总体和测试天数）和构建效度（收敛效度和已知组分析）：参与者完成了 80.1% 的测试。点记忆的信度为 0.98，符号搜索的信度为 0.99。点记忆的信度在 3 天内达到 ⩾0.90，符号搜索的信度在 1 天内达到 ⩾0.90。符号搜索得分与神经心理学测试的处理速度有显著相关性（rs 范围 = |0.53-0.69|），并因残疾程度（t = -3.95，p < 0.001）和多发性硬化症亚型（t = -2.81，p = 0.005）而有显著差异。点记忆得分与工作记忆的神经心理学测试相关（rs 范围 = |0.45-0.58|）；点记忆得分不因残疾程度或多发性硬化症亚型而异：结论：智能手机管理的工作记忆和处理速度测试在多发性硬化症中表现出良好的可行性、可靠性和构建有效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Multiple Sclerosis Journal 医学-临床神经学

CiteScore

10.90

自引率

6.90%

发文量

186

审稿时长

3-8 weeks

期刊介绍： Multiple Sclerosis Journal is a peer-reviewed international journal that focuses on all aspects of multiple sclerosis, neuromyelitis optica and other related autoimmune diseases of the central nervous system. The journal for your research in the following areas: * __Biologic basis:__ pathology, myelin biology, pathophysiology of the blood/brain barrier, axo-glial pathobiology, remyelination, virology and microbiome, immunology, proteomics * __Epidemology and genetics:__ genetics epigenetics, epidemiology * __Clinical and Neuroimaging:__ clinical neurology, biomarkers, neuroimaging and clinical outcome measures * __Therapeutics and rehabilitation:__ therapeutics, rehabilitation, psychology, neuroplasticity, neuroprotection, and systematic management Print ISSN: 1352-4585