Advanced Nanomedicine Delivery Systems for Cardiovascular Diseases: Viral and Non-Viral Strategies in Targeted Therapy.

IF 4.6 2区化学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Molecules Pub Date : 2025-02-19 DOI:10.3390/molecules30040962

Qian Chen, Tong Yu, Jingyi Gong, Hongli Shan

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Abstract

Cardiovascular diseases (CVDs) represent a leading global health crisis, significantly impairing patients' quality of life and posing substantial risks to their survival. Conventional therapies for CVDs often grapple with challenges such as inadequate targeting precision, suboptimal therapeutic efficacy, and potential adverse side effects. To address these shortcomings, researchers are intensively developing advanced drug delivery systems characterized by high specificity and selectivity, excellent biodegradability, superior biocompatibility, and minimal toxicity. These innovative systems enable the precise delivery of pharmaceuticals with high drug-loading capacities, minimal leakage, and expansive specific surface areas, thereby enhancing therapeutic outcomes. In this review, we summarize and classify various drug delivery materials targeting CVDs and application values. We also evaluate the feasibility and efficacy of viral and non-viral vectors for the treatment of CVDs, the existing limitations and application prospects are also discussed. We hope that this review will provide new perspectives for the future development of drug delivery systems for the treatment of CVDs, ultimately contributing to improved patient care and outcomes.

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心血管疾病的先进纳米药物递送系统：靶向治疗中的病毒和非病毒策略。

心血管疾病是一种主要的全球健康危机，严重损害患者的生活质量，并对其生存构成重大风险。传统的心血管疾病治疗方法经常面临一些挑战，如靶向精度不高、治疗效果不理想以及潜在的不良副作用。为了解决这些缺点，研究人员正在集中开发具有高特异性和选择性、优异的生物可降解性、优越的生物相容性和最小毒性的先进药物传递系统。这些创新的系统能够精确地递送药物，具有高载药能力，最小的泄漏和广阔的比表面积，从而提高治疗效果。本文就针对心血管疾病的各种给药材料及其应用价值进行综述和分类。本文还对病毒载体和非病毒载体治疗心血管疾病的可行性和疗效进行了评价，并对现有的局限性和应用前景进行了讨论。我们希望这篇综述将为心血管疾病治疗药物输送系统的未来发展提供新的视角，最终有助于改善患者的护理和结果。

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来源期刊

Molecules 化学-有机化学

CiteScore

7.40

自引率

8.70%

发文量

7524

审稿时长

1.4 months

期刊介绍： Molecules (ISSN 1420-3049, CODEN: MOLEFW) is an open access journal of synthetic organic chemistry and natural product chemistry. All articles are peer-reviewed and published continously upon acceptance. Molecules is published by MDPI, Basel, Switzerland. Our aim is to encourage chemists to publish as much as possible their experimental detail, particularly synthetic procedures and characterization information. There is no restriction on the length of the experimental section. In addition, availability of compound samples is published and considered as important information. Authors are encouraged to register or deposit their chemical samples through the non-profit international organization Molecular Diversity Preservation International (MDPI). Molecules has been launched in 1996 to preserve and exploit molecular diversity of both, chemical information and chemical substances.