Preparation and application of enzyme-based hydrogels

IF 10.61 Q3 Biochemistry, Genetics and Molecular Biology Biosensors and Bioelectronics: X Pub Date : 2025-02-20 DOI:10.1016/j.biosx.2025.100594

Yahui Wen , Xinghai Wang , Jinxue Zhao , Xuejing Zhai , Wei Xia , Peiyi Li , Keqiang Lai , Lidong Wu

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Abstract

Enzymes are highly efficient catalysts in nature, governing countless reactions in biological systems. Enzyme-based hydrogels are three-dimensional network materials with enzyme activity, created by loading enzymes into hydrogels or using hydrogels to synthesize polymeric materials. Due to their high biocompatibility, enzyme-based hydrogels exhibit broad application potential in various fields. In recent years, researchers have been continuously exploring new preparation methods to improve the physical, chemical, and biological properties of enzyme-based hydrogels. Additionally, the introduction of materials such as graphene, carbon nanotubes, and metal-organic frameworks (MOFs) has further enhanced the biological activity of these hydrogels. This review summarizes recent preparation methods and structural characteristics of enzyme-based hydrogels, with a focus on their applications in biosensors and medical fields, highlighting the vast application prospects of enzyme-based hydrogels.

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酶基水凝胶的制备与应用

酶是自然界中高效的催化剂，控制着生物系统中无数的反应。酶基水凝胶是一种具有酶活性的三维网络材料，通过将酶装载到水凝胶中或利用水凝胶合成聚合物材料而产生。酶基水凝胶具有较高的生物相容性，在各个领域具有广泛的应用潜力。近年来，研究人员不断探索新的制备方法，以提高酶基水凝胶的物理、化学和生物性能。此外，石墨烯、碳纳米管和金属有机框架（mof）等材料的引入进一步增强了这些水凝胶的生物活性。本文综述了近年来酶基水凝胶的制备方法和结构特点，重点介绍了酶基水凝胶在生物传感器和医学领域的应用，强调了酶基水凝胶的广阔应用前景。

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来源期刊

Biosensors and Bioelectronics: X Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

4.60

自引率

0.00%

发文量

166

审稿时长

54 days

期刊介绍： Biosensors and Bioelectronics: X, an open-access companion journal of Biosensors and Bioelectronics, boasts a 2020 Impact Factor of 10.61 (Journal Citation Reports, Clarivate Analytics 2021). Offering authors the opportunity to share their innovative work freely and globally, Biosensors and Bioelectronics: X aims to be a timely and permanent source of information. The journal publishes original research papers, review articles, communications, editorial highlights, perspectives, opinions, and commentaries at the intersection of technological advancements and high-impact applications. Manuscripts submitted to Biosensors and Bioelectronics: X are assessed based on originality and innovation in technology development or applications, aligning with the journal's goal to cater to a broad audience interested in this dynamic field.