Lignin derived carbon capped CuO assisted one pot synthesis of quinazolines and its antibacterial activity

IF 5.4 3区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR Inorganic Chemistry Communications Pub Date : 2025-05-01 Epub Date: 2025-02-21 DOI:10.1016/j.inoche.2025.114166

Kathar Aazath , Kumar Aravindraj , Sagayaraj Jane Anto Simplica , Selvaraj Mohana Roopan , Murugan Arunachalapandi , Ashokan Anju Kanjirakkandy , Mohanasrinivasan Vaithilingam

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Abstract

A new nanocomposite system based on carbon supported CuO material was designed and confirmed by various techniques, such as XRD, FTIR, UV–Vis, PL and FE-SEM. A straightforward and scalable procedure that involves carbonizing lignin deposited on the surface of copper oxide nanoparticles produces CuO/C nanocomposites. In this study, CuO/C nanocomposites were used as photocatalysts for a one-pot synthesis of quinazolines under blue light irradiation. The catalyst showed excellent activity for synthesizing quinazolines (8 examples) with higher yield (84–94%) and easy recovery from the reaction mixture. The recovered CuO/C nanocomposites were used for 5 consecutive cycles, without significant loss of its catalytic activity. The synthesized compounds were also tested for antibacterial activity, and they exhibited considerable activity. This research will pave the way for the investigation of the use of lignin-derived carbon as a substrate for other types of nanoparticles, resulting in the creation of novel, eco-friendly catalysts for a variety of organic reactions.

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木质素衍生碳包盖氧化铜辅助一锅合成喹唑啉类药物及其抑菌活性

采用XRD、FTIR、UV-Vis、PL和FE-SEM等技术对碳负载CuO材料的纳米复合体系进行了设计和验证。一个简单和可扩展的过程，包括碳化木质素沉积在氧化铜纳米颗粒表面产生CuO/C纳米复合材料。本文以CuO/C纳米复合材料为光催化剂，在蓝光照射下一锅法合成了喹唑啉类化合物。该催化剂催化合成喹唑啉类化合物（8例），产率高（84 ~ 94%），且易于从反应混合物中回收。回收的CuO/C纳米复合材料连续使用5次，其催化活性没有明显损失。合成的化合物还进行了抗菌活性测试，显示出相当大的活性。这项研究将为木质素衍生的碳作为其他类型纳米颗粒的底物的研究铺平道路，从而创造出用于各种有机反应的新型环保催化剂。

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来源期刊

Inorganic Chemistry Communications 化学-无机化学与核化学

CiteScore

5.50

自引率

7.90%

发文量

1013

审稿时长

53 days

期刊介绍： Launched in January 1998, Inorganic Chemistry Communications is an international journal dedicated to the rapid publication of short communications in the major areas of inorganic, organometallic and supramolecular chemistry. Topics include synthetic and reaction chemistry, kinetics and mechanisms of reactions, bioinorganic chemistry, photochemistry and the use of metal and organometallic compounds in stoichiometric and catalytic synthesis or organic compounds.