Clinical study of the diagnosis of thyroid tumours using Raman spectroscopy

IF 1.8 4区医学 Q2 OTORHINOLARYNGOLOGY Brazilian Journal of Otorhinolaryngology Pub Date : 2025-05-01 Epub Date: 2025-02-28 DOI:10.1016/j.bjorl.2025.101568

Qingjian He , Lianjin Qin , Yongqiang Yao , WenJuan Wang

{"title":"Clinical study of the diagnosis of thyroid tumours using Raman spectroscopy","authors":"Qingjian He , Lianjin Qin , Yongqiang Yao , WenJuan Wang","doi":"10.1016/j.bjorl.2025.101568","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>The feasibility of the RS for the clinical diagnosis of thyroid tumours was explored.</div></div><div><h3>Methods</h3><div>The tumour specimens from 30 benign patients and 30 malignant patients were collected. The collected specimens were subjected to RS and histopathological analysis. The Raman peak intensities of all the specimens were calculated, and the data were analysed using discriminant analysis.</div></div><div><h3>Results</h3><div>(1) The prevalence rate of malignant tumours in females was as high as 76.7%. Central lymph node metastasis of malignant thyroid tumours accounted for 33.3% of cases, and lateral cervical lymph node metastasis accounted for only 6.7%. (2) The spectral intensity of malignant thyroid tumours was significantly greater than benign thyroid tumours at 1309 cm<sup>−1</sup>, which should be the characteristic peak of thyroid cancer. The accuracy, sensitivity, and specificity of the RS for differentiating benign from malignant thyroid tumours were 95%, 83.3% and 89.2%.</div></div><div><h3>Conclusion</h3><div>RS is feasible for the diagnosis of thyroid tumours. This study provides experimental and clinical support for the wider application of RS in the evaluation of thyroid tissue.</div></div><div><h3>Levels of evidence</h3><div>: Levels 4.</div></div>","PeriodicalId":49099,"journal":{"name":"Brazilian Journal of Otorhinolaryngology","volume":"91 3","pages":"Article 101568"},"PeriodicalIF":1.8000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brazilian Journal of Otorhinolaryngology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1808869425000114","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/28 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

The feasibility of the RS for the clinical diagnosis of thyroid tumours was explored.

Methods

The tumour specimens from 30 benign patients and 30 malignant patients were collected. The collected specimens were subjected to RS and histopathological analysis. The Raman peak intensities of all the specimens were calculated, and the data were analysed using discriminant analysis.

Results

(1) The prevalence rate of malignant tumours in females was as high as 76.7%. Central lymph node metastasis of malignant thyroid tumours accounted for 33.3% of cases, and lateral cervical lymph node metastasis accounted for only 6.7%. (2) The spectral intensity of malignant thyroid tumours was significantly greater than benign thyroid tumours at 1309 cm⁻¹, which should be the characteristic peak of thyroid cancer. The accuracy, sensitivity, and specificity of the RS for differentiating benign from malignant thyroid tumours were 95%, 83.3% and 89.2%.

Conclusion

RS is feasible for the diagnosis of thyroid tumours. This study provides experimental and clinical support for the wider application of RS in the evaluation of thyroid tissue.

Levels of evidence

: Levels 4.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

拉曼光谱诊断甲状腺肿瘤的临床研究

目的探讨磁共振成像在甲状腺肿瘤临床诊断中的可行性。方法收集良性肿瘤标本30例，恶性肿瘤标本30例。采集标本进行RS和组织病理学分析。计算所有标本的拉曼峰强度，并对数据进行判别分析。结果(1)女性恶性肿瘤患病率高达76.7%。甲状腺恶性肿瘤中央淋巴结转移占33.3%，颈侧淋巴结转移仅占6.7%。(2)恶性甲状腺肿瘤的光谱强度在1309 cm−1处明显大于良性甲状腺肿瘤，这应该是甲状腺癌的特征峰。RS鉴别甲状腺良恶性肿瘤的准确性、敏感性和特异性分别为95%、83.3%和89.2%。结论rs对甲状腺肿瘤的诊断是可行的。本研究为RS在甲状腺组织评价中的更广泛应用提供了实验和临床支持。证据等级：四级。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Brazilian Journal of Otorhinolaryngology OTORHINOLARYNGOLOGY-

CiteScore

3.00

自引率

0.00%

发文量

205

审稿时长

4-8 weeks

期刊介绍： Brazilian Journal of Otorhinolaryngology publishes original contributions in otolaryngology and the associated areas (cranio-maxillo-facial surgery and phoniatrics). The aim of this journal is the national and international divulgation of the scientific production interesting to the otolaryngology, as well as the discussion, in editorials, of subjects of scientific, academic and professional relevance. The Brazilian Journal of Otorhinolaryngology is born from the Revista Brasileira de Otorrinolaringologia, of which it is the English version, created and indexed by MEDLINE in 2005. It is the official scientific publication of the Brazilian Association of Otolaryngology and Cervicofacial Surgery. Its abbreviated title is Braz J Otorhinolaryngol., which should be used in bibliographies, footnotes and bibliographical references and strips.