Synthesis and Analgesic Activity of Ureas and Imidazolidine-2,4,5-trione Derivatives Containing Adamantane and Monoterpene Fragments

IF 0.8 4区 化学 Q4 CHEMISTRY, MULTIDISCIPLINARY Russian Journal of General Chemistry Pub Date : 2025-02-27 DOI:10.1134/S1070363224612808
P. E. Rogozin, E. V. Suslov, A. Yu. Filippova, A. V. Pavlova, K. P. Volcho, N. F. Salakhutdinov
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Abstract

A series of ureas and substituted parabanic acids containing monoterpene and adamantane fragments were synthesized. It was found that urea containing a (–)-menthone residue, as well as an imidazolidine-2,4,5-trione derivative with a (+)-campholenaldehyde moiety, exhibit analgesic activity.

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含金刚烷和单萜的脲类和咪唑烷-2,4,5-三酮衍生物的合成及镇痛活性研究
合成了一系列含有单萜烯和金刚烷片段的脲和取代对羟基苯甲酸。发现含有(-)-薄荷酮残留的尿素和含有(+)-樟脑醛部分的咪唑烷-2,4,5-三酮衍生物具有镇痛活性。
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来源期刊
CiteScore
1.40
自引率
22.20%
发文量
252
审稿时长
2-4 weeks
期刊介绍: Russian Journal of General Chemistry is a journal that covers many problems that are of general interest to the whole community of chemists. The journal is the successor to Russia’s first chemical journal, Zhurnal Russkogo Khimicheskogo Obshchestva (Journal of the Russian Chemical Society ) founded in 1869 to cover all aspects of chemistry. Now the journal is focused on the interdisciplinary areas of chemistry (organometallics, organometalloids, organoinorganic complexes, mechanochemistry, nanochemistry, etc.), new achievements and long-term results in the field. The journal publishes reviews, current scientific papers, letters to the editor, and discussion papers.
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