Clinical translation of metabolomics markers in endometrial carcinoma

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY Journal of Obstetrics and Gynaecology Research Pub Date : 2025-02-27 DOI:10.1111/jog.16246

Nur Fatin Nabilah Mohd Sahardi, Manishaa Priya, Suzana Makpol, Mohamad Nasir Shafiee

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Abstract

Objective

This comprehensive review highlights the current research on metabolomics and the metabolic pathways involved in endometrial cancer (EC), offering potential non-invasive biomarkers for EC.

Methods

The data was extracted from published manuscripts between 2015 and 2024 using the reputed search engine “Pubmed.” All gathered data were organized into a single table, facilitating a comparison with earlier findings.

Results

The results of this study revealed most metabolites identified in previous metabolomic research on EC are associated with lipid, glucose, and amino acid metabolism.

Conclusion

Therefore, understanding these metabolic pathway alterations in EC is crucial for improving diagnosis, prognosis, and treatments by specially targeting these metabolic pathways.

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子宫内膜癌代谢组学标志物的临床翻译

目的综述子宫内膜癌代谢组学及代谢途径的研究进展，为子宫内膜癌提供潜在的非侵入性生物标志物。方法通过知名搜索引擎“Pubmed”提取2015 - 2024年发表的论文。所有收集到的数据被整理成一个表格，便于与早期的发现进行比较。结果本研究结果显示，在以往的代谢组学研究中发现的大多数代谢产物与脂质、葡萄糖和氨基酸代谢有关。因此，了解这些代谢途径的改变对改善EC的诊断、预后和治疗具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Obstetrics and Gynaecology Research 医学-妇产科学

CiteScore

3.10

自引率

0.00%

发文量

376

审稿时长

3-6 weeks

期刊介绍： The Journal of Obstetrics and Gynaecology Research is the official Journal of the Asia and Oceania Federation of Obstetrics and Gynecology and of the Japan Society of Obstetrics and Gynecology, and aims to provide a medium for the publication of articles in the fields of obstetrics and gynecology. The Journal publishes original research articles, case reports, review articles and letters to the editor. The Journal will give publication priority to original research articles over case reports. Accepted papers become the exclusive licence of the Journal. Manuscripts are peer reviewed by at least two referees and/or Associate Editors expert in the field of the submitted paper.