Daniela Bacherini MD, PhD , Stefano Mercuri MD , Andrea Govetto MD, PhD , Laura Di Leo MD , Tomaso Caporossi MD , Francesco Faraldi MD , Stanislao Rizzo MD , Gianni Virgili MD , Fabrizio Giansanti MD, PhD
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引用次数: 0
Abstract
Purpose
To describe the morphology and provide anatomical correlations of supra-retinal pigment epithelium (RPE) granular deposits in full-thickness macular holes (FTMHs).
Patients with idiopathic FTMH presenting to the University of Florence Eye clinic.
Methods
Thirty-six eyes of 34 patients with a diagnosis of treatment-naive FTMH, scheduled for surgery, underwent multimodal imaging including spectral-domain OCT (SD-OCT), en-face OCT, and adaptive optics ophthalmoscopy (AOO). Different methodologies were evaluated to determine the location and topographical correspondence of granulations. The total volume of supra-RPE granular deposits was correlated to the macular hole (MH) characteristics and SD-OCT markers of photoreceptor damage with Spearman correlation coefficient (CC).
Main Outcome Measures
Morphological correlations in FTMHs using SD-OCT and AOO.
Results
Using AOO, supra-RPE granular deposits appeared as hyper-reflective structures, mostly found within the minimum linear diameter (MLD) (104 of 139 deposits, 74%). Different imaging techniques were equally effective in the topographical identification of supra-RPE granular deposits (P > 0.30). The total volume of supra-RPE granular deposits significantly increased with stages B and C of FTMH, inversely correlated to the corrected ellipsoid zone (EZ) reflectivity (CC = −0.62) and positively correlated to the length of the EZ defect (CC = +0.41) and MH diameter at the base (CC = +0.35) and MLD (CC = +0.42) (all P < 0.05).
Conclusions
Supra-RPE granular deposits can be identified accurately using AOO and en-face OCT. Characteristics using AOO and anatomical correlations at SD-OCT indicate supra-RPE granular deposits as signs of photoreceptor degeneration.
Financial Disclosure(s)
The authors have no proprietary or commercial interest in any materials discussed in this article.
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