Ophthalmology. Retina最新文献

英文中文

Novel CNNM4 Variant Causing Jalili Syndrome in Identical Twin Sisters. 新CNNM4变异导致同卵双胞胎姐妹的贾利利综合征。

IF 5.7 Q1 OPHTHALMOLOGY

Ophthalmology. Retina

Pub Date : 2026-01-09 DOI: 10.1016/j.oret.2025.12.015

Utsav Shah, Srikanta Kumar Padhy

引用次数: 0

Progressive Foveal Involvement in Congenital Hypertrophy of the Retinal Pigment Epithelium. 先天性视网膜色素上皮肥大的进行性中央窝受累。

IF 5.7 Q1 OPHTHALMOLOGY

Ophthalmology. Retina

Pub Date : 2026-01-09 DOI: 10.1016/j.oret.2025.12.012

Pedro Carreira, Prithvi Ramtohul, Diogo Cabral

引用次数: 0

Intraocular Solitary Fibrous Tumor. 眼内孤立性纤维性肿瘤。

IF 5.7 Q1 OPHTHALMOLOGY

Ophthalmology. Retina

Pub Date : 2026-01-08 DOI: 10.1016/j.oret.2025.12.011

Yang Meng, Sainan Xiao, Tao Li

引用次数: 0

Malabsorption Syndromes and Risk of Age-Related Macular Degeneration: Evidence from Real-World Data. 吸收不良综合征和年龄相关性黄斑变性的风险：来自真实世界数据的证据。

IF 5.7 Q1 OPHTHALMOLOGY

Ophthalmology. Retina

Pub Date : 2026-01-08 DOI: 10.1016/j.oret.2026.01.002

Hejin Jeong, Priya S Eppel, David C Kaelber, Rishi P Singh, Katherine E Talcott

Purpose: Despite mechanistic links connecting malnutrition and gut microbiome with retinal health, clinical research exploring the relationship between malabsorption syndromes and age-related macular degeneration (AMD) remains limited. This study compared the risks of AMD diagnosis in patients with and without various malabsorption syndrome diagnoses.

Design: Retrospective cohort study of aggregated, de-identified patient data from multiple healthcare organizations across the United States using the TriNetX U.S. Collaborative Research Network in 11/2025.

Participants: Adults with a cataract-related International Classification of Diseases (ICD) encounter diagnosis codes and no baseline AMD ICD encounter diagnosis codes were divided into groups based on the presence of ICD encounter diagnosis codes for celiac disease (CeD), ulcerative colitis (UC), Crohn's disease (CrD), chronic pancreatitis (CP), and short bowel syndrome (SBS). Within the CP cohort, patients with pancreatic enzyme replacement therapy (PERT) prescription orders were subanalysis. For each cohort, a corresponding control cohort of patients without the respective ICD encounter diagnosis codes was created.

Methods: The study and control cohorts were propensity-matched 1:1 on demographic factors, comorbidities, and disease-related conditions and prescription orders. The matched cohorts were compared on the risk of having AMD ICD encounter diagnoses.

Main outcome measure: Risk ratios (RR) and 95% confidence intervals (CI) of having an AMD ICD encounter diagnosis code with an accompanying retinal optical coherence tomography Common Procedural Terminology code. Significance was defined as CI ≤0.9 or ≥1.1.

Results: Compared to controls without IBD, the CrD cohort (n=9,537, RR=1.42, CI=1.16-1.74), but not the UC cohort (n=15,039, RR=1.28, CI=1.09-1.51), had a higher risk of having early/intermediate AMD. CP was associated with an increased risk of AMD (n=12,856, RR=1.82, CI=1.53-2.16), even in the PERT subset (n=3,812, RR=1.83, CI=1.35-2.48). SBS (n=3,747) was associated with an increased risk of advanced/exudative AMD (RR=1.98, CI=1.31-2.98), but not early/intermediate AMD (RR=1.28, CI=0.96-1.71). CeD was not associated with increased AMD risk (n=9,315, RR=1.09, CI=0.88-1.35).

Conclusions: Chronic non-infectious causes of malabsorption syndromes-CrD, CP, and SBS-may represent underrecognized risk factors of AMD. This explorative study adds clinical evidence for a potential role of the gut-retina axis in the pathogenesis of AMD.

目的：尽管营养不良和肠道微生物组与视网膜健康之间存在机制联系，但探索吸收不良综合征与年龄相关性黄斑变性（AMD）之间关系的临床研究仍然有限。本研究比较了有和没有各种吸收不良综合征诊断的患者AMD诊断的风险。设计：回顾性队列研究，使用TriNetX美国合作研究网络，于2025年11月对来自美国多个医疗保健组织的汇总、去识别的患者数据进行研究。参与者：具有白内障相关国际疾病分类（ICD）遇到诊断代码和无基线AMD ICD遇到诊断代码的成年人根据是否存在乳糜泻（CeD）、溃疡性结肠炎（UC）、克罗恩病（CrD）、慢性胰腺炎（CP）和短肠综合征（SBS）的ICD遇到诊断代码分为两组。在CP队列中，对接受胰酶替代疗法（PERT）处方的患者进行亚分析。对于每个队列，创建一个相应的对照队列，其中没有相应的ICD遭遇诊断代码。方法：研究组和对照组在人口学因素、合并症、疾病相关条件和处方上按1:1的倾向性匹配。比较匹配的队列患AMD ICD遭遇诊断的风险。主要结果测量：AMD ICD遇到诊断代码并伴随视网膜光学相干断层扫描通用程序术语代码的风险比（RR）和95%置信区间（CI）。显著性定义为CI≤0.9或≥1.1。结果：与没有IBD的对照组相比，CrD组（n= 9537， RR=1.42， CI=1.16-1.74）有更高的早期/中期AMD风险，而UC组（n= 15039， RR=1.28， CI=1.09-1.51）没有。CP与AMD风险增加相关（n=12,856， RR=1.82， CI=1.53-2.16），即使在PERT子集中也是如此（n=3,812， RR=1.83， CI=1.35-2.48）。SBS （n=3,747）与晚期/渗出性AMD的风险增加相关（RR=1.98， CI=1.31-2.98），但与早期/中期AMD无关（RR=1.28， CI=0.96-1.71）。CeD与AMD风险增加无关（n=9,315， RR=1.09， CI=0.88-1.35）。结论：慢性非感染性吸收不良综合征（crd、CP和sbs）可能是AMD未被充分认识的危险因素。这项探索性研究为肠-视网膜轴在AMD发病机制中的潜在作用提供了临床证据。

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引用次数: 0

Corrigendum.

IF 5.7 Q1 OPHTHALMOLOGY

Ophthalmology. Retina

Pub Date : 2026-01-07 DOI: 10.1016/j.oret.2025.12.017

引用次数: 0

Vitreoretinal Abnormalities in Poretti-Boltshauser Syndrome: An Imaging Overview. porretti - boltshauser综合征的玻璃体视网膜异常：影像学综述。

IF 5.7 Q1 OPHTHALMOLOGY

Ophthalmology. Retina

Pub Date : 2026-01-07 DOI: 10.1016/j.oret.2025.12.010

Samet Gulkas, Ines Fenniri, Anne Fulton

引用次数: 0

Aggressive-Retinopathy of Prematurity or Oxygen-Induced Retinopathy? 侵袭性：早产儿视网膜病变还是氧致视网膜病变？

IF 5.7 Q1 OPHTHALMOLOGY

Ophthalmology. Retina

Pub Date : 2026-01-07 DOI: 10.1016/j.oret.2025.12.009

Abhishek Singh, Deepshikha Agrawal, Anil Babanrao Gangwe

引用次数: 0

Resolution of Retained Perfluoro-n-Octane After Retinal Detachment Repair. 视网膜脱离修复后残留全氟辛烷的溶解

IF 5.7 Q1 OPHTHALMOLOGY

Ophthalmology. Retina

Pub Date : 2026-01-06 DOI: 10.1016/j.oret.2025.12.007

Walton Spivey, Victor T Copeland, Mohan N Iyer

引用次数: 0

Arteriovenous Malformation with Central Retinal Vein Occlusion and Intraretinal Hyporeflective Spaces 动静脉畸形伴视网膜中央静脉闭塞和视网膜内低反射间隙。

IF 5.7 Q1 OPHTHALMOLOGY

Ophthalmology. Retina

Pub Date : 2026-01-01 DOI: 10.1016/j.oret.2025.04.018

Andrea Coletto MD , Valerie Krivosic MD , Elodie Bousquet MD, PhD

引用次数: 0

Internal Limiting Membrane Peeling for Grade C Proliferative Vitreoretinopathy 内限制膜剥离治疗C级增殖性玻璃体视网膜病变的疗效：一项国际多中心研究。

IF 5.7 Q1 OPHTHALMOLOGY

Ophthalmology. Retina

Pub Date : 2026-01-01 DOI: 10.1016/j.oret.2025.06.006

Taku Wakabayashi MD, PhD , Annika G. Samuelson MD , Yusuke Oshima MD, PhD , Vishal Swaminathan MD , Akihiko Shiraki MD , Bita Momenaei MD , Anahita Sehgal MD , Satoshi Imamura MD , Yuichiro Ishida MD , Keita Baba MD , David Xu MD , Nobuhiko Shiraki MD, PhD , Hisashi Fukuyama MD , Kotaro Tsuboi MD , Ava Torjani MD , Robert M. Abishek MD , Michael N. Cohen MD , Ajay E. Kuriyan MD , Carl H. Park MD , Marc J. Spirn MD , Yoshihiro Yonekawa MD

Purpose

To evaluate the efficacy of internal limiting membrane (ILM) peeling on the anatomic and visual outcomes of pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment (RRD) with grade C proliferative vitreoretinopathy (PVR).

Design

Multicenter, interventional, clinical cohort study.

Subjects

Consecutive patients who underwent PPV for grade C PVR with a minimum of 6-month follow-up.

Methods

We compared the anatomic and visual outcomes of grade C PVR surgery after vitrectomy with PVR membrane peeling plus, or without, ILM peeling, in patients treated at 6 institutions between January 2015 and January 2022. Internal limiting membrane peeling was performed within the macula, arcade to arcade, or beyond the arcades (extended ILM peeling).

Main Outcome Measures

Single surgery anatomic success at 3 months and 6 months with versus without ILM peeling.

Results

We included a total of 370 eyes (370 patients); 157 eyes (42.4%) treated with ILM peeling were compared with 213 eyes (57.6%) treated without ILM peeling. Mean follow-up was 23.2 ± 13.9 months. No differences were noted in baseline characteristics or surgical techniques. Single surgery anatomic success was significantly higher in the ILM peeling group (86.6% vs. 73.2% at 3 months [P = 0.002] and 75.2% vs. 65.3% at 6 months [P = 0.041], respectively). The retinal reattachment rate under fluid without tamponade was significantly higher in the ILM peeling group at 6 months (68.8% vs. 51.6%, P < 0.001). Both groups showed visual improvement after surgery (both P < 0.001). However, the ILM peeling group showed significantly better visual acuity and visual improvement (1.11 ± 0.70 vs. 1.29 ± 0.80 [P = 0.020] and 0.48 ± 0.77 vs. 0.24 ± 0.90 [P = 0.018], respectively). The ILM peeling group had significantly fewer subsequent vitreoretinal surgeries (P = 0.002), including subsequent epiretinal membrane surgeries (8.9% vs. 17.8%, P = 0.015). No ILM peeling was associated with more posterior breaks when the retina redetached (P = 0.045). Multivariable regression analysis showed that extended ILM peeling was significantly associated with higher likelihood of retinal reattachment without tamponade (under fluid) at 6 months and better final visual acuity (P = 0.040 and 0.031, respectively).

Conclusions

Internal limiting membrane peeling, particularly extended ILM peeling, for RRD with grade C PVR resulted in superior anatomic and visual outcomes compared with vitrectomy without ILM peeling in this study.

Financial Disclosure(s)

Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

目的：探讨内限制膜（ILM）剥离对玻璃体平面部切除术（PPV）治疗孔源性视网膜脱离（RRD）合并C级增殖性玻璃体视网膜病变（PVR）的解剖和视觉效果的影响。设计：多中心、介入、临床队列研究。受试者：连续接受PPV治疗的c级PVR患者，随访至少6个月。方法：我们比较了2015年1月至2022年1月期间在6家机构接受玻璃体切除术后，PVR膜剥离加ILM剥离的c级PVR手术的解剖和视觉结果。在黄斑内、街机间或街机外进行ILM剥离（扩展ILM剥离）。主要结局指标：单次手术解剖成功（SSAS）在3个月和6个月有与没有ILM剥离。结果：我们共纳入370只眼（370例患者）；有ILM剥落者157只眼（42.4%），未剥落者213只眼（57.6%）。平均随访23.2±13.9个月。在基线特征或手术技术方面没有差异。ILM剥皮组的SSAS显著升高（3个月时为86.6% vs. 73.2%， 6个月时为75.2% vs. 65.3%）（P分别=0.002和0.041）。6个月时，在无压塞的液体下，ILM剥离组的视网膜再附着率显著高于前者（68.8% vs. 51.6%）。结论：对于伴有C级PVR的RRD， ILM剥离，特别是延长的ILM剥离，与没有ILM剥离的玻璃体切除术相比，在本研究中具有更好的解剖和视觉效果。

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