Da Woon Lee, Si-Hyong Jang, Hyun Kim, Taek Kyun Kim, Je Yeon Byeon, Hwan Jun Choi
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引用次数: 0
Abstract
Background: Silicone nasal implants have been widely used in rhinoplasty. However, research on the correlation between implant hardness and the development of fibrosis and inflammation is lacking. This study investigated how the hardness of silicone implants influences fibrosis and inflammation through an experimental investigation.
Methods: Three types of nasal silicone implants with varying hardness levels were implanted bilaterally on the backs of 15 Wistar rats. Ten weeks after implantation, clinical aspects-such as differences in immune reactions and formation of peri-implant capsules-were analyzed. The intratissue response of the host was assessed by quantitative real-time polymerase chain reaction using 11 markers. Specific markers were investigated by immunohistochemical staining. Pathologic grading was performed to investigate inflammation and fibrosis in the peri-implant tissues. Quantification and statistical analysis of these parameters were conducted to derive scores for intergroup comparisons.
Results: Histologic analysis of the 45 capsules obtained revealed lower levels of fibrosis and acute inflammation in the group with lower hardness. This result was confirmed by immunohistochemical staining. Hematoxylin and eosin staining showed that the capsule thickness was less in the low-hardness group. In addition, inflammation resolved quickly in the low-hardness group, and mature fibrotic tissue was observed.
Conclusions: When silicone implants are stably positioned within the body, less-rigid implants exhibit lower inflammatory or fibrotic responses. This is directly related to the adverse effects associated with capsule formation. These findings contribute to our understanding of the behavior of heterotopic materials in the nasal dorsum and their effects on the skin and soft-tissue envelope.
Clinical relevance statement: This study highlights the impact of implant hardness on rhinoplasty outcomes, with softer implants reducing inflammation and fibrosis. Plastic surgeons should prioritize softer silicone implants to lower complication risks and improve long-term results.
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For more than 70 years Plastic and Reconstructive Surgery® has been the one consistently excellent reference for every specialist who uses plastic surgery techniques or works in conjunction with a plastic surgeon. Plastic and Reconstructive Surgery® , the official journal of the American Society of Plastic Surgeons, is a benefit of Society membership, and is also available on a subscription basis.
Plastic and Reconstructive Surgery® brings subscribers up-to-the-minute reports on the latest techniques and follow-up for all areas of plastic and reconstructive surgery, including breast reconstruction, experimental studies, maxillofacial reconstruction, hand and microsurgery, burn repair, cosmetic surgery, as well as news on medicolegal issues. The cosmetic section provides expanded coverage on new procedures and techniques and offers more cosmetic-specific content than any other journal. All subscribers enjoy full access to the Journal''s website, which features broadcast quality videos of reconstructive and cosmetic procedures, podcasts, comprehensive article archives dating to 1946, and additional benefits offered by the newly-redesigned website.
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