The Dose-response of Blood Pressure Variability in Stroke and Coronary Heart Disease.

Abstract

Introduction/ Objective: Blood pressure variability (BPV) is a potential predictor of vascular events and triggers target organ damage. This study aimed to determine the BPV in stroke and coronary heart disease (CHD) in the Bogor Cohort Study in Indonesia.

Methods: Over six years of monitoring, a prospective cohort study was conducted on 1649 respondents aged ≥ 31 years from the Bogor Non-communicable Diseases Risk Factors Cohort Study. The dependent variable was vascular events (stroke or CHD), which were new cases (incidents) that appeared during the 6-year monitoring period (2011 - 2017 and 2012-2018).

Result: During the six years of monitoring, the incidence of vascular events was 12.4 percent. The dose-response of systolic and diastolic BPV in vascular events, stroke, and coronary heart disease showed an increased risk (quintiles Q2, Q3, and Q4) compared to quintile 1 (Q1). Systolic BPV of ≥12,10 mmHg and diastolic BPV of ≥ 7,31 mmHg had a risk of 2.3 and 1.7 (95% Confidence Intervals (CI)), respectively, for vascular events during the period of 6-year observation, after controlling for age, hypertension status, and lipid profile.

Conclusion: BPV is an independent predictor of vascular events, stroke, and coronary heart disease. The public and clinicians must pay attention to controlling BPV as a risk factor for vascular events, stroke, and CHD.