The unseen climate health risks of antimicrobial resistance in urban informal settlements

IF 50 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Nature Medicine Pub Date : 2025-02-28 DOI:10.1038/s41591-025-03548-3
Karin Leder, Brett Davis, S. Fiona Barker, Fiona Lynch, Rebekah Henry
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城市非正式住区抗菌素耐药性的无形气候健康风险
全世界有超过10亿人居住在发展中城市的非正式住区,缺乏基本的基础设施和服务,如安全的卫生设施和清洁的水。这些社区占中低收入国家城市人口的20-40%,通常位于易受洪水影响或不稳定的边缘土地上,是受气候变化影响最严重的群体之一。更频繁和严重的洪水、极端和不可避免的高温、风暴、风暴潮和水资源短缺的情况,以及海平面上升的生存威胁,已经对这些社区的居民产生了不成比例的影响,与此同时,这些社区的一些人是应对这些不利条件的资源最少的。然而,除了这些可见的实际威胁之外,城市非正式住区还有许多环境因素使其成为健康风险的热点。作为重振非正式住区及其环境(RISE)项目的一部分,我们在印度尼西亚望加锡和斐济苏瓦的24个美国社区进行了为期六年的逐户调查和微生物学、空间环境采样,深入了解了这些住区面临的许多逆境和健康挑战。这些发现指出了导致美国社区健康风险的一系列因素,包括:缺乏有效的卫生设施导致粪便废物被排放到高密度的城市社区;反复发生水浸及排水系统欠佳,导致本地及上游污水排放的含病原体的水持续淤积;缺乏适当的道路和通道,导致行人经常穿过受污染的水域和沉积物;住房、地板和厕所设施质量差;获得清洁水的机会很少或有限;密切接触家畜和野生动物、牲畜、害虫和昆虫;健康素养欠佳。由于缺乏清洁的通道和进入家庭的通道,造成居民,特别是儿童,与外部粪便污染的环境反复密切接触和相互作用,然后可能将其带入家中。因此,这些社区的居民长期、习惯性地接触致病性病原体,表现为频繁和复发的局部感染细菌性疾病的高发率。在儿童中,儿童早期疾病负担的影响会产生长期后果,如贫血、发育迟缓和认知发育不良4。
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来源期刊
Nature Medicine
Nature Medicine 医学-生化与分子生物学
CiteScore
100.90
自引率
0.70%
发文量
525
审稿时长
1 months
期刊介绍: Nature Medicine is a monthly journal publishing original peer-reviewed research in all areas of medicine. The publication focuses on originality, timeliness, interdisciplinary interest, and the impact on improving human health. In addition to research articles, Nature Medicine also publishes commissioned content such as News, Reviews, and Perspectives. This content aims to provide context for the latest advances in translational and clinical research, reaching a wide audience of M.D. and Ph.D. readers. All editorial decisions for the journal are made by a team of full-time professional editors. Nature Medicine consider all types of clinical research, including: -Case-reports and small case series -Clinical trials, whether phase 1, 2, 3 or 4 -Observational studies -Meta-analyses -Biomarker studies -Public and global health studies Nature Medicine is also committed to facilitating communication between translational and clinical researchers. As such, we consider “hybrid” studies with preclinical and translational findings reported alongside data from clinical studies.
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