In Situ Synthesis of CNT-Bridged UiO-66-(COOH)2 on Polytetrafluoroethylene Porous Membrane for Portable Hemodialysis

Abstract

A portable home hemodialysis device is a miniaturized and easy-to-operate medical apparatus designed for patients with chronic kidney disease, enabling them to conveniently perform hemodialysis at home or while traveling. However, it imposes high requirements on the dialysis membrane in terms of dialysis efficiency, adsorption capacity, and blood compatibility. In this study, the composite membrane was fabricated through electrospinning, which is an in situ synthesis of carbon nano tube (CNT)bridged UiO66(COOH)₂ on PTFE fibers. UiO66(COOH)₂ increased the adsorption site by association with CNT, and achieved the adsorption of creatinine by hydrogen bond and π bond, which greatly reduced the usage of dialysis solution. UiO66(COOH)₂ and CNT were first combined for creatinine adsorption, and its maximum static adsorption capacity was 66 mg/g. During the dialysis, the yielding membrane showed a creatinine clearance of 64.89% and a resistance protein rate of more than 98%. Compared with pure PTFE dialysis membrane, the amount of dialysate used to achieve the same dialysis effect was merely 1/10. Furthermore, the membrane has a hemolysis rate of 2% and a low platelet adhesion rate, which shows excellent blood compatibility. Therefore, the dialysis membrane prepared in this study is expected to promote the development of portable home hemodialysis devices.