{"title":"Overcoming (some) rules in synthesis design.","authors":"Reinhard W Hoffmann","doi":"10.1039/d4cs01120a","DOIUrl":null,"url":null,"abstract":"<p><p>The experience gained in the development of science is codified in dogmas, rules, and directives. Such originally helpful rules are not necessarily cast in concrete, as they may become obsolete because of newer challenges and developments. This is manifested by breakthroughs violating such rules. Three examples concerning synthesis design in Organic Chemistry are discussed in this essay.</p>","PeriodicalId":68,"journal":{"name":"Chemical Society Reviews","volume":" ","pages":""},"PeriodicalIF":40.4000,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Society Reviews","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d4cs01120a","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
The experience gained in the development of science is codified in dogmas, rules, and directives. Such originally helpful rules are not necessarily cast in concrete, as they may become obsolete because of newer challenges and developments. This is manifested by breakthroughs violating such rules. Three examples concerning synthesis design in Organic Chemistry are discussed in this essay.
期刊介绍：
Chemical Society Reviews is published by: Royal Society of Chemistry.
Focus: Review articles on topics of current interest in chemistry;
Predecessors: Quarterly Reviews, Chemical Society (1947–1971);
Current title: Since 1971;
Impact factor: 60.615 (2021);
Themed issues: Occasional themed issues on new and emerging areas of research in the chemical sciences
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