{"title":"Ruthenium-catalyzed monodeuterium-methylenation of two indole units with vinylene carbonate as a novel methylene precursor.","authors":"Jiang Nan, Lulu Xu, Rui Cao","doi":"10.1039/d4cc06204c","DOIUrl":null,"url":null,"abstract":"<p><p>A new example of deuteration, involving ruthenium-catalyzed monodeuterium-methylenation of indole units with vinylene carbonate, is described. This reaction was used to build an array of promising highly deuterated bisindolylmethanes (d-BIMs). This methodology featured excellent functional group compatibility with diverse substrate categories such as indoles, <i>N</i>,<i>N</i>-dialkylanilines, and 1,3-dicarbonyls as well as having showcased the distinct chemical function of VC as an innovative methylene precursor.</p>","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":" ","pages":""},"PeriodicalIF":4.3000,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Communications","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d4cc06204c","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
A new example of deuteration, involving ruthenium-catalyzed monodeuterium-methylenation of indole units with vinylene carbonate, is described. This reaction was used to build an array of promising highly deuterated bisindolylmethanes (d-BIMs). This methodology featured excellent functional group compatibility with diverse substrate categories such as indoles, N,N-dialkylanilines, and 1,3-dicarbonyls as well as having showcased the distinct chemical function of VC as an innovative methylene precursor.
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