{"title":"Ruthenium-catalyzed monodeuterium-methylenation of two indole units with vinylene carbonate as a novel methylene precursor†","authors":"Jiang Nan , Lulu Xu , Rui Cao","doi":"10.1039/d4cc06204c","DOIUrl":null,"url":null,"abstract":"<div><div>A new example of deuteration, involving ruthenium-catalyzed monodeuterium-methylenation of indole units with vinylene carbonate, is described. This reaction was used to build an array of promising highly deuterated bisindolylmethanes (d-BIMs). This methodology featured excellent functional group compatibility with diverse substrate categories such as indoles, <em>N</em>,<em>N</em>-dialkylanilines, and 1,3-dicarbonyls as well as having showcased the distinct chemical function of VC as an innovative methylene precursor.</div></div>","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"61 24","pages":"Pages 4718-4721"},"PeriodicalIF":4.2000,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Communications","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1359734525003763","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
A new example of deuteration, involving ruthenium-catalyzed monodeuterium-methylenation of indole units with vinylene carbonate, is described. This reaction was used to build an array of promising highly deuterated bisindolylmethanes (d-BIMs). This methodology featured excellent functional group compatibility with diverse substrate categories such as indoles, N,N-dialkylanilines, and 1,3-dicarbonyls as well as having showcased the distinct chemical function of VC as an innovative methylene precursor.
期刊介绍：
ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
