Prognostic significance of systemic immune inflammation index for ovarian cancer: An updated systematic review and meta-analysis.

IF 4.2 3区医学 Q1 REPRODUCTIVE BIOLOGY Journal of Ovarian Research Pub Date : 2025-02-27 DOI:10.1186/s13048-025-01626-1

Boliang Chu, Yingying Chen, Jiewei Pan

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Abstract

Objective: Several inflammatory indices have been used to assess the prognosis of ovarian cancer, with variable results. This review assessed whether the systemic immune inflammation index (SII) can predict outcomes in patients with ovarian cancer.

Methods: Embase, PubMed, CENTRAL, Web of Science, and Scopus databases were searched by the two reviewers from inception to 15th October 2024 for studies assessing the relationship between SII and overall survival (OS) or disease-free survival (DFS).

Results: Ten studies with eleven cohorts were included. Pooled analysis showed that higher SII was a significant predictor of poor OS (HR: 2.35 95% CI: 1.56, 3.55 I² = 88%) and worse DFS (HR: 2.51 95% CI: 1.71, 3.67 I² = 80%) after ovarian cancer. Sensitivity analysis failed to change the significance of the results. No publication bias was noted. Most results remained significant on subgroup analyses based on location, sample size, FIGO stage, treatment, adjusted outcomes, cut-off of SII, method of determining cut-off, and quality score.

Conclusions: SII can be a potential predictor of OS and DFS after ovarian cancer. Further studies are required to improve the evidence.

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系统性免疫炎症指数对卵巢癌的预后意义：一项最新的系统综述和荟萃分析。

目的：几种炎症指标被用来评估卵巢癌的预后，结果不一。本综述评估了系统性免疫炎症指数（SII）是否可以预测卵巢癌患者的预后。方法：两位审稿人检索了Embase、PubMed、CENTRAL、Web of Science和Scopus数据库，从成立到2024年10月15日，检索了评估SII与总生存期（OS）或无病生存期（DFS）之间关系的研究。结果：纳入了10项研究，共11个队列。合并分析显示，较高的SII是卵巢癌后较差的OS （HR: 2.35 95% CI: 1.56, 3.55 I2 = 88%）和较差的DFS （HR: 2.51 95% CI: 1.71, 3.67 I2 = 80%）的显著预测因子。敏感性分析不能改变结果的显著性。未发现发表偏倚。大多数结果在基于地点、样本量、FIGO分期、治疗、调整结局、SII截断值、确定截断值的方法和质量评分的亚组分析中仍然具有显著性。结论：SII可作为卵巢癌术后OS和DFS的潜在预测因子。需要进一步的研究来完善证据。

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来源期刊

Journal of Ovarian Research REPRODUCTIVE BIOLOGY-

CiteScore

6.20

自引率

2.50%

发文量

125

审稿时长

>12 weeks

期刊介绍： Journal of Ovarian Research is an open access, peer reviewed, online journal that aims to provide a forum for high-quality basic and clinical research on ovarian function, abnormalities, and cancer. The journal focuses on research that provides new insights into ovarian functions as well as prevention and treatment of diseases afflicting the organ. Topical areas include, but are not restricted to: Ovary development, hormone secretion and regulation Follicle growth and ovulation Infertility and Polycystic ovarian syndrome Regulation of pituitary and other biological functions by ovarian hormones Ovarian cancer, its prevention, diagnosis and treatment Drug development and screening Role of stem cells in ovary development and function.