{"title":"Deciphering the oxidative stress response in Candida albicans","authors":"Víctor Arribas , Concha Gil , Gloria Molero","doi":"10.1016/j.fbr.2025.100427","DOIUrl":null,"url":null,"abstract":"<div><div><em>Candida</em> species are the leading cause of invasive fungal infections, with <em>Candida albicans</em> being the most common one. Consequently, the World Health Organization has included <em>C. albicans</em> in its fungal priority pathogens list. Following infection, phagocytes (mostly macrophages) initiate a respiratory burst, producing oxidant compounds, such as hydrogen peroxide. In response, <em>C. albicans</em> activates a robust oxidative stress response to catalyze the oxidant molecules produced by the immune system and counteract their oxidative effects within the cell. The oxidative stress response of <em>C. albicans</em> implies proteomic changes, both in abundance and in post-translational modifications, that are not fully described yet. Proteins with immediate antioxidant properties, the MAPK signaling pathways, and transcription factors are involved in the response. In this review, we discuss the role of these factors and the interactions among them in <em>C. albicans.</em> Many of these mechanisms act as virulence traits that favor the invasive candidiasis and can be used as potential targets for antifungal drugs.</div></div>","PeriodicalId":12563,"journal":{"name":"Fungal Biology Reviews","volume":"52 ","pages":"Article 100427"},"PeriodicalIF":5.7000,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Fungal Biology Reviews","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S174946132500017X","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MYCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Candida species are the leading cause of invasive fungal infections, with Candida albicans being the most common one. Consequently, the World Health Organization has included C. albicans in its fungal priority pathogens list. Following infection, phagocytes (mostly macrophages) initiate a respiratory burst, producing oxidant compounds, such as hydrogen peroxide. In response, C. albicans activates a robust oxidative stress response to catalyze the oxidant molecules produced by the immune system and counteract their oxidative effects within the cell. The oxidative stress response of C. albicans implies proteomic changes, both in abundance and in post-translational modifications, that are not fully described yet. Proteins with immediate antioxidant properties, the MAPK signaling pathways, and transcription factors are involved in the response. In this review, we discuss the role of these factors and the interactions among them in C. albicans. Many of these mechanisms act as virulence traits that favor the invasive candidiasis and can be used as potential targets for antifungal drugs.
期刊介绍:
Fungal Biology Reviews is an international reviews journal, owned by the British Mycological Society. Its objective is to provide a forum for high quality review articles within fungal biology. It covers all fields of fungal biology, whether fundamental or applied, including fungal diversity, ecology, evolution, physiology and ecophysiology, biochemistry, genetics and molecular biology, cell biology, interactions (symbiosis, pathogenesis etc), environmental aspects, biotechnology and taxonomy. It considers aspects of all organisms historically or recently recognized as fungi, including lichen-fungi, microsporidia, oomycetes, slime moulds, stramenopiles, and yeasts.