An Injectable Copolymer for in Situ Lubrication Effectively Relieves Dry Eye Disease

IF 8.7 1区化学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY ACS Materials Letters Pub Date : 2025-02-07 DOI:10.1021/acsmaterialslett.4c02327

Lan Yang, Jinghua Li, Bowen Zhou and Yi Wang*,

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Abstract

The current lubricating artificial tear ingredient for dry eye disease (DED) therapy, i.e., sodium hyaluronate (SH), is ineffective because it is difficult to stay on the ocular surface long term. To address this problem, we developed an injectable in situ lubricative copolymer that can firmly adhere to the ocular surface for long-lasting in situ lubrication. Lubrication was achieved by the zwitterionic monomer [2-((methacryloyl)oxy)ethyl]phosphorylcholine (MPC) with hydration lubrication property. Meanwhile, in situ adhesion performance was achieved by the reactive ester monomer N-hydroxysuccinimidyl acrylate (AA-NHS), which is capable of amide bonding reactions to the tissue surface. The optimum feeding ratio of MPC versus AA-NHS for free radical polymerization was confirmed by friction tests, and this group was named MPC-co-AA-NHS (MAN). We established a BALB/c mice DED model to verify its biofunctionality in vivo. The results showed that MAN is a promising in situ lubrication material that effectively relieves DED.

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一种可注射共聚物原位润滑有效缓解干眼症

目前用于干眼病（DED）治疗的润滑人工泪液成分，即透明质酸钠（SH），由于其难以长期停留在眼表上而无效。为了解决这个问题，我们开发了一种可注射的原位润滑共聚物，它可以牢固地附着在眼表面，实现持久的原位润滑。采用具有水化润滑性能的两性离子单体[2-（（甲基丙烯酰）氧）乙基]磷酸胆碱（MPC）实现润滑。同时，反应性酯单体n -羟基琥珀酰丙烯酸酯（AA-NHS）实现了原位粘附性能，该酯单体能够与组织表面发生酰胺键合反应。通过摩擦试验确定了MPC与AA-NHS进行自由基聚合的最佳投料比，并将其命名为MPC-co-AA-NHS （MAN）。我们建立了BALB/c小鼠DED模型来验证其在体内的生物功能。结果表明，MAN是一种很有前途的原位润滑材料，可以有效缓解DED。

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来源期刊

ACS Materials Letters MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

14.60

自引率

3.50%

发文量

261

期刊介绍： ACS Materials Letters is a journal that publishes high-quality and urgent papers at the forefront of fundamental and applied research in the field of materials science. It aims to bridge the gap between materials and other disciplines such as chemistry, engineering, and biology. The journal encourages multidisciplinary and innovative research that addresses global challenges. Papers submitted to ACS Materials Letters should clearly demonstrate the need for rapid disclosure of key results. The journal is interested in various areas including the design, synthesis, characterization, and evaluation of emerging materials, understanding the relationships between structure, property, and performance, as well as developing materials for applications in energy, environment, biomedical, electronics, and catalysis. The journal has a 2-year impact factor of 11.4 and is dedicated to publishing transformative materials research with fast processing times. The editors and staff of ACS Materials Letters actively participate in major scientific conferences and engage closely with readers and authors. The journal also maintains an active presence on social media to provide authors with greater visibility.

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