Photoacoustic oxygenation imaging to identify ischemia/hypoxia injury and necrosis of intestine after acute intussusception: A comparative study with CDFI/CEUS

IF 6.8 1区医学 Q1 ENGINEERING, BIOMEDICAL Photoacoustics Pub Date : 2025-06-01 Epub Date: 2025-03-01 DOI:10.1016/j.pacs.2025.100706

Hualin Yan , Zehui Gou , Hong Wang , Xiaoxia Zhu , Juxian Liu , Wenwu Ling , Lin Huang , Yan Luo

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Abstract

Acute intussusception is a pediatric abdominal emergency that requires immediate diagnosis and treatment. However, accurately identifying bowel necrosis non-invasively remains challenging with conventional sonography. In our study, we investigated the potential of photoacoustic imaging (PAI) as an innovative method for assessing ischemia/hypoxia injury and intestinal necrosis in cases of acute intussusception. Using PAI, we measured intestinal oxygen saturation (sO₂) levels and total hemoglobin (HbT) in various models of acute intussusception at different time points. Additionally, we evaluated blood supply and ischemia/hypoxia injury using color Doppler flow imaging (CDFI) and contrast-enhanced ultrasound (CEUS). Based on histopathological results, intestinal sO₂ measured by PAI demonstrated optimal diagnostic performance for both ischemia/hypoxia injury and intestinal necrosis, with AUC values of 0.997 and 0.982, respectively, while CDFI and CEUS showed relatively high diagnostic performance for both ischemia/hypoxia injury and intestinal necrosis. In conclusion, PAI represents a promising, non-invasive imaging modality for assessing acute intussusception.

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光声氧合成像识别急性肠套叠后肠缺血/缺氧损伤和坏死：与CDFI/CEUS的比较研究

急性肠套叠是一种需要立即诊断和治疗的儿科腹部急症。然而，准确地无创地识别肠坏死仍然是传统超声检查的挑战。在我们的研究中，我们探讨了光声成像（PAI）作为一种评估急性肠套叠患者缺血/缺氧损伤和肠坏死的创新方法的潜力。采用PAI测定不同时间点急性肠套叠模型的肠氧饱和度（sO2）水平和总血红蛋白（HbT）。此外，我们使用彩色多普勒血流成像（CDFI）和对比增强超声（CEUS）评估血液供应和缺血/缺氧损伤。组织病理学结果显示，PAI测定肠道sO 2对缺血/缺氧损伤和肠坏死的诊断效果最佳，AUC分别为0.997和0.982，而CDFI和CEUS对缺血/缺氧损伤和肠坏死的诊断效果均较高。总之，PAI是评估急性肠套叠的一种有前途的、无创的成像方式。

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来源期刊

Photoacoustics Physics and Astronomy-Atomic and Molecular Physics, and Optics

CiteScore

11.40

自引率

16.50%

发文量

审稿时长

53 days

期刊介绍： The open access Photoacoustics journal (PACS) aims to publish original research and review contributions in the field of photoacoustics-optoacoustics-thermoacoustics. This field utilizes acoustical and ultrasonic phenomena excited by electromagnetic radiation for the detection, visualization, and characterization of various materials and biological tissues, including living organisms. Recent advancements in laser technologies, ultrasound detection approaches, inverse theory, and fast reconstruction algorithms have greatly supported the rapid progress in this field. The unique contrast provided by molecular absorption in photoacoustic-optoacoustic-thermoacoustic methods has allowed for addressing unmet biological and medical needs such as pre-clinical research, clinical imaging of vasculature, tissue and disease physiology, drug efficacy, surgery guidance, and therapy monitoring. Applications of this field encompass a wide range of medical imaging and sensing applications, including cancer, vascular diseases, brain neurophysiology, ophthalmology, and diabetes. Moreover, photoacoustics-optoacoustics-thermoacoustics is a multidisciplinary field, with contributions from chemistry and nanotechnology, where novel materials such as biodegradable nanoparticles, organic dyes, targeted agents, theranostic probes, and genetically expressed markers are being actively developed. These advanced materials have significantly improved the signal-to-noise ratio and tissue contrast in photoacoustic methods.