Determination of ternary stability constants for metal complexes of succinic acid dihydrazide and glycine using pH-Metric analysis in aqueous medium

Abstract

A Chemometric modelling study in order to assess stability constants of type [MmLlXxHh] was carried out using pH metric technique under the conditions of 303K and 0.1 mol dm⁻³ ionic strength for the divalent Calcium, and Magnesium with X = Glycine, L = Succinic acid dihydrazide (SADH). Succinic acid dihydrazide is a novel, ditopic, non-toxic ligand that is able to bind two metal ions simultaneously in aqueous medium. The best-fit chemical models were obtained for the determination of stability constants using MINIQUAD-75 programme, and various statistical parameters were considered in this process. Simulation of pH metric data was done to obtain the simulated and experimental titration curves; Hyperquad Simulation and Speciation software (HySS) was used to generate concentration distribution diagrams. The Δ log K formulation was employed to do quantitative assessments of the relative stabilities of ternary complexes in comparison to binary species.