Frontispiz: Selbstassemblierung von Amorphen 2D-Polymer-Nanoscheiben mit Einstellbarer Größe, pH-Abhängigem Abbau und Kontrollierter Wirkstofffreisetzung

Abstract

Amphiphilic bottlebrush block copolymers with hydrophobic brush segments self-assemble into nanodiscs in water. Their size, pH-responsiveness, and drug loading capacity can be controlled. Different hydrolysis rates enable time-dependent degradation and drug release. In their Communication (e202424269), Markus MÃ1/4llner et al. show how the functional nanodisc core can switch from hydrophobic to hydrophilic, allowing loaded cargo to be released.