Angewandte Chemie最新文献

Achieving specific interactions of metal-oxo clusters with biological substrates becomes possible through organic functionalization. The illustration depicts a dartboard that symbolizes the enzyme's active site as the molecular target. The darts represent clusters bearing distinct organic functionalities, designed to enable selective interactions with the protein surface. This concept highlights the potential of molecular design strategies to achieve precise bioinorganic recognition. More in the Communication (e202518349) by Mhamad Aly Moussawi, Tatjana N. Parac-Vogt, and co-workers.

A carbonothioate-based fluorescent probe is developed that can be selectively activated by H₂S_n (n > 1) through cascade cyclization reaction to liberate the phenolic fluorophore. This work for the first time demonstrates the fluorescence imaging of H₂S_n dynamics in insulin-resistant cells and type 2 diabetes mellitus (T2DM) mice. Details are reported by Wei Chen and co-workers in their Research Article (e202519021).

We report the synthesis of a planarized tris-amidobismuthane supported by a rigid, bulky NNN pincer ligand, which enforces a T-shaped geometry at the bismuth center. The Bi(NNN) complex features a low-lying LUMO with distinct Bi(6p) orbital character as shown by DFT calculations. Cyclic voltammetry reveals a fully reversible one-electron reduction at E_1/2 = –1.85 V versus Fc^0/+ in THF. Chemical reduction with KC₈ in the presence of 4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane (222-crypt) enables the isolation of an unprecedented Bi(II) radical anion in high isolated yields. Multi-frequency EPR, X-ray absorption spectroscopy and SQUID magnetometry complemented by theoretical calculations confirm localization of the unpaired electron on the bismuth center. Preliminary reactivity studies display radical reactivity as shown by single-electron transfer chemistry and radical coupling reactions.

The famous French impressionist painter Claude Monet painted the portal of Rouen Cathedral many times between 1892 and 1894. Observing the same model, he attempted to capture the moment under different lighting conditions and at different times of the day. Inspired from this masterpiece, the Research Article by Hani Amouri, Andreas Steffen et al. (e202515695) illustrates a new class of carbene Au-alkynyl complexes where inorganic and organic chromphores merge in harmony to generate anti-Kasha panchromatic emitters, which emit over the entire visible spectrum under different excitation wavelengths.

One-pot assembly of arabinogalactans from the Mycobacterium tuberculosis cell wall up to the 92-mer has been achieved based on glycosyl ortho-(1-phenylvinyl)benzoates, precluding aglycone transfer issues inherent to one-pot glycan assembly with thioglycosides. Structure–conformation–activity relationship studies revealed that the surface-exposed 30-mer induced a modest NF-κB activation while preserving cell viability (e202515896).

Chemical gardens are self-assembled architectures with “life-like” morphologies that form in the absence of any biological activity. In their Communication (e202508098), Matthias Kellermeier et al. show that such structures can also be obtained by contacting reservoirs of calcium and sulfate ions, under conditions that plausibly emulate those prevailing on early Mars. Our results demonstrate that mineralization in purely inorganic, sulfate-rich environments can produce solid matter with biomimetic shapes and may thus lead to false-positive detection of life on the red planet.

Mechanical activation in ball-milling mechanochemistry remains experimentally elusive, prompting the theoretical exploration in the Research Article (e202505263) by Ivan Halasz, Ana-Sunčana Smith, and co-workers. Using molecular simulations, mechanochemical impacts under neat and liquid-assisted grinding are modelled, capturing how kinetic energy from the impact drives crystal fragmentation into atoms, ions, and ion pairs, triggering product formation and agglomeration. It is shown that minimal liquid promotes reactivity, while excess stabilizes reactants. This framework enables rational optimization of catalysts and reaction conditions.

Local electric fields guide protons toward the heme through two distinct electrostatic funnels at the γ- and δ-edges in heme peroxidases. Water-mediated pathways enable proton exchange with key residues such as Arg38 and His42. These findings reveal that nature pre-organizes electrostatic funnels and solvent channels to provide multiple, well-defined routes for proton delivery, conserved across heme peroxidase enzymes. More in the Research Article (e202515743) by Reynier Suardíaz, Emma L. Raven, Adrian J. Mulholland, and co-workers.

Calcium metal nanoparticles (5.4 ± 1.2 nm) are realized by TMEDA-supported reduction of CaI₂ with [LiNaph] in toluene. Their reactivity is exemplarily evaluated in the liquid phase and results in [{(^DippNacNac)(thf)Ca}₂(naph)] with a rare naphthalenide dianion, [{(^DippNacNac)(thf)CaMo(Cp)H}₂(fulvalene)] with unusual MoH → Ca dative bonding, and [Au₉(PPh₃)₈](naph)(tmeda)_0.5 with a non-charged body-centered cubic Au₉ cluster core of zerovalent gold. More in the Research Article (e15995) by Wim Klopper, Claus Feldmann, and co-workers.

The cover illustrates light-induced chemiluminescence (CL) microscopy, proposed to visualize heterogeneous photocatalytic activity on individual photocatalysts in a controlled spatiotemporal way. In their Research Article (e202509277), Taeyoon Kim and Joohoon Kim demonstrate the potential of CL microscopy by revealing the spatial heterogeneity in photo-Fenton-type activity of dendritic hematite within a single hematite photocatalyst, as well as the unique activity distribution among individual photocatalysts in a population of hematite structures of different shapes and sizes.