A chromatin mesh model for compaction of chromatin by PRC1 in condensates

IF 10.1 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Nature Structural & Molecular Biology Pub Date : 2025-03-03 DOI:10.1038/s41594-025-01504-w

Nicole J. Francis

引用次数: 0

Abstract

The structure of chromatin bound by Polycomb repressive complex 1 (PRC1) and how it contributes to transcription repression are unknown. Here, cryo-electron tomography (cryo-ET) of PRC1–chromatin condensates reveal randomly oriented neighboring nucleosomes in a stable, open chromatin mesh that might exclude large protein complexes to repress transcription.

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凝析油中PRC1压实染色质的染色质网格模型

多梳抑制复合体1 （Polycomb repression complex 1, PRC1）结合的染色质结构及其对转录抑制的作用尚不清楚。在这里，prc1 -染色质凝聚物的冷冻电子断层扫描（cro - et）显示，在一个稳定、开放的染色质网中，随机定向的邻近核小体可能会排除大的蛋白质复合物来抑制转录。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Structural & Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOPHYSICS

CiteScore

22.00

自引率

1.80%

发文量

160

审稿时长

3-8 weeks

期刊介绍： Nature Structural & Molecular Biology is a comprehensive platform that combines structural and molecular research. Our journal focuses on exploring the functional and mechanistic aspects of biological processes, emphasizing how molecular components collaborate to achieve a particular function. While structural data can shed light on these insights, our publication does not require them as a prerequisite.

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