Precise Genotyping Via Surface-Enhanced Raman Spectroscopy-Based Optical Sensing Chip for Guiding Targeted Therapy in Lung Cancer (Laser Photonics Rev. 19(5)/2025)
Min Fan, Jingbo Chen, Xiaomeng Zheng, Luyun Xu, Jianqin Ye, Xueliang Lin, Kien Voon Kong, Duo Lin, Yudong Lu, Shangyuan Feng
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引用次数: 0
Abstract
Optical Biosensing Chip
In article number 2401400, Duo Lin, Yudong Lu, Shangyuan Feng and co-workers propose an optical biosensing platform based on SERS for genotyping cancer-related circulating tumor DNA, thereby enabling the precise screening of populations benefiting from targeted therapy. In addition, this liquid biopsy technology was integrated with a portable Raman scanning system and customized algorithm software to develop a compact genotyping instrument. Follow-up clinical experiments suggest that this optical instrument is capable of accurately identifying EGFR mutations, and consequently precisely guiding targeted therapy in lung cancer.
期刊介绍：
Laser & Photonics Reviews is a reputable journal that publishes high-quality Reviews, original Research Articles, and Perspectives in the field of photonics and optics. It covers both theoretical and experimental aspects, including recent groundbreaking research, specific advancements, and innovative applications.
As evidence of its impact and recognition, Laser & Photonics Reviews boasts a remarkable 2022 Impact Factor of 11.0, according to the Journal Citation Reports from Clarivate Analytics (2023). Moreover, it holds impressive rankings in the InCites Journal Citation Reports: in 2021, it was ranked 6th out of 101 in the field of Optics, 15th out of 161 in Applied Physics, and 12th out of 69 in Condensed Matter Physics.
The journal uses the ISSN numbers 1863-8880 for print and 1863-8899 for online publications.
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