Bio-inspired nanozymes with smartphone-assisted sensor platform for colorimetric detection of ascorbic acid in fruits and supplements

IF 4.9 2区化学 Q1 CHEMISTRY, ANALYTICAL Microchemical Journal Pub Date : 2025-05-01 Epub Date: 2025-03-01 DOI:10.1016/j.microc.2025.113192

Jun Li , Zue Hu , Yi Peng , Hui Yang , Qian Zhou , Nan Wang , Xianggui Chen , Xiaoqi Yu

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Abstract

Nanozymes have become one of the key applications in the analysis and sensing of food. However, nanozymes presented have shortcomings that limit their further application, such as complex raw material sources, and high condition requirements for synthesis. Cu-GSSG nanozymes under green preparation conditions were synthesized inspired by the detoxification process of glutathione in living organisms. Cu-GSSG nanozymes were further loaded onto filter paper to construct a smartphone-assisted colorimetric sensor test strip for ascorbic acid (AA) detection. As the excellent peroxidase-like enzymes, Cu-GSSG nanozymes showed low AA detection limit of 2.9 μM with a wide linear range of 10–300 μM. Cu-GSSG nanozymes exhibited excellent anti-interference, accuracy, and biocompatibility performances for reliable detection AA in prickly pear juice and 10 supplements. The intelligent colorimetric sensor platform based on the bio-inspired Cu-GSSG nanozymes showed the great potential in rapid detection and large-scale screening of AA in fruits and supplements.

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仿生纳米酶与智能手机辅助传感器平台，用于水果和补充剂中抗坏血酸的比色检测

纳米酶已成为食品分析和传感领域的关键应用之一。然而，纳米酶存在原料来源复杂、合成条件要求高等缺点，限制了其进一步应用。受生物体内谷胱甘肽解毒过程的启发，在绿色制备条件下合成了Cu-GSSG纳米酶。将Cu-GSSG纳米酶进一步加载到滤纸上，构建智能手机辅助比色传感器检测抗坏血酸（AA）的试纸条。Cu-GSSG纳米酶作为优异的过氧化物酶类酶，其AA检测限低，为2.9 μM，线性范围为10 ~ 300 μM。Cu-GSSG纳米酶具有良好的抗干扰性、准确性和生物相容性，可可靠地检测花椒汁和10种补充剂中的AA。基于仿生Cu-GSSG纳米酶的智能比色传感器平台在水果和补充剂中AA的快速检测和大规模筛选方面显示出巨大的潜力。

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文献相关原料

公司名称

产品信息

阿拉丁

5,5-dimethyl-1-pyrroline N-oxide (DMPO)

阿拉丁

3,3′,5,5′-tetramethylbenzidine (TMB)

阿拉丁

Glutathione (GSH)

来源期刊

Microchemical Journal 化学-分析化学

CiteScore

8.70

自引率

8.30%

发文量

1131

审稿时长

1.9 months

期刊介绍： The Microchemical Journal is a peer reviewed journal devoted to all aspects and phases of analytical chemistry and chemical analysis. The Microchemical Journal publishes articles which are at the forefront of modern analytical chemistry and cover innovations in the techniques to the finest possible limits. This includes fundamental aspects, instrumentation, new developments, innovative and novel methods and applications including environmental and clinical field. Traditional classical analytical methods such as spectrophotometry and titrimetry as well as established instrumentation methods such as flame and graphite furnace atomic absorption spectrometry, gas chromatography, and modified glassy or carbon electrode electrochemical methods will be considered, provided they show significant improvements and novelty compared to the established methods.