Dar Yoffe , Joseph GR. Paturzo , Alexandra Payne , Erin Hays , Michael Markel , Gaurav Bandi
{"title":"Paraneoplastic limbic encephalitis secondary to sertoli cell testicular tumor: A case report","authors":"Dar Yoffe , Joseph GR. Paturzo , Alexandra Payne , Erin Hays , Michael Markel , Gaurav Bandi","doi":"10.1016/j.eucr.2025.102995","DOIUrl":null,"url":null,"abstract":"<div><div>Paraneoplastic Limbic Encephalitis (PLE) is a neurocognitive condition caused by an immune response to neuronal proteins linked to malignancy, such as testicular cancer. We report a 25-year-old male with cognitive and personality changes. <u>His initial</u> MRI showed vasogenic edema. <u>A subsequent</u> CT scan revealed bilateral hydroceles, and a follow-up scrotal US uncovered a right testicular mass, leading to a radical orchiectomy that confirmed a Sertoli cell tumor. Following orchiectomy and immunomodulating therapy, the patient's symptoms showed near-complete <u>resolution</u> within a year. This is the first documented case of PLE resulting from a non-germ cell testicular tumor.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"60 ","pages":"Article 102995"},"PeriodicalIF":0.4000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Urology Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S221444202500066X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/1 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Paraneoplastic Limbic Encephalitis (PLE) is a neurocognitive condition caused by an immune response to neuronal proteins linked to malignancy, such as testicular cancer. We report a 25-year-old male with cognitive and personality changes. His initial MRI showed vasogenic edema. A subsequent CT scan revealed bilateral hydroceles, and a follow-up scrotal US uncovered a right testicular mass, leading to a radical orchiectomy that confirmed a Sertoli cell tumor. Following orchiectomy and immunomodulating therapy, the patient's symptoms showed near-complete resolution within a year. This is the first documented case of PLE resulting from a non-germ cell testicular tumor.
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