Ex-vivo optical prognosis of fibroadenoma and grade ll & lll breast cancer.

IF 2.4 4区 医学 Q3 ENGINEERING, BIOMEDICAL Lasers in Medical Science Pub Date : 2025-03-01 DOI:10.1007/s10103-025-04285-2
Munir Akhtar, Muhammad Abubakar Siddique, Muhammad Abdul Majid, Shahida Parveen, Rubaida Mehmood, Sumara Ashraf, Irum Fida, Wesam Atef Hatamleh, Muhammad Umar Dad, Hafeez Ullah
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Abstract

Among women worldwide, breast cancer is one of the most common cancers results from the growth of cancerous cells. This work investigates 87 patients using polarimetry in the visible spectral range (400-800 nm). Polarimetry is used for tissue characterization, particularly to prognosis cancer and biochemical quantification. Nine derived polarization properties were compared for both malignant and benign breast tissue. All nine polarimetric properties have high values for Grade III as compared to grade II and fibroadenoma. Benign tumours have higher anisotropy than malignant tumors. Ellipticity and orientation exhibit an inverse tendency. Hematology shows that moringa significantly improves the blood components of breast cancer. Pearson & Spearman correlation analysis was used with level of significance p < 0.05 where' p' is probability that the observed effect within the study would have occurred by chance. All parameters and components show significance level expect Leukocytes, Urea, Creatinine, SGOT and Bilirubin Total. Model training is a difficult procedure that determines the quality of application upon which it is deployed. Our data produces the accuracy 82.8%, with 1360 observations and 38 predictors. Thus a framework for breast cancer prognosis is provided by the combination of polarisation analysis, math and classification techniques.

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纤维腺瘤和ⅱ、ⅱ级乳腺癌的离体光学预后。
在全世界的女性中,乳腺癌是由癌细胞生长引起的最常见的癌症之一。本研究使用偏振法在可见光谱范围(400-800 nm)对87例患者进行了研究。偏振法用于组织表征,特别是预后癌症和生化定量。比较了恶性和良性乳腺组织的9种衍生极化特性。与II级和纤维腺瘤相比,III级的所有9个极化特征值都很高。良性肿瘤比恶性肿瘤具有更高的各向异性。椭圆度与取向呈反比趋势。血液学显示辣木能显著改善乳腺癌的血液成分。采用Pearson & Spearman相关分析,显著性水平为p
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来源期刊
Lasers in Medical Science
Lasers in Medical Science 医学-工程:生物医学
CiteScore
4.50
自引率
4.80%
发文量
192
审稿时长
3-8 weeks
期刊介绍: Lasers in Medical Science (LIMS) has established itself as the leading international journal in the rapidly expanding field of medical and dental applications of lasers and light. It provides a forum for the publication of papers on the technical, experimental, and clinical aspects of the use of medical lasers, including lasers in surgery, endoscopy, angioplasty, hyperthermia of tumors, and photodynamic therapy. In addition to medical laser applications, LIMS presents high-quality manuscripts on a wide range of dental topics, including aesthetic dentistry, endodontics, orthodontics, and prosthodontics. The journal publishes articles on the medical and dental applications of novel laser technologies, light delivery systems, sensors to monitor laser effects, basic laser-tissue interactions, and the modeling of laser-tissue interactions. Beyond laser applications, LIMS features articles relating to the use of non-laser light-tissue interactions.
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