Factors associated with vaccination against mpox in people under preexposure prophylaxis against HIV in the Community of Madrid.

Abstract

Introduction: In May 2022, a mpox outbreak was identified in Europe. The majority of those affected are young men with risky sexual relations. In Spain, to control the outbreak, vaccination is recommended, among others, for people on HIV pre-exposure prophylaxis (PrEP). The objective of the study is to determine the factors associated with vaccination against mpox in people included in PrEP in the Community of Madrid.

Methods: Descriptive study. The sources of information used are: the PrEP Registry, Health Card, the Vaccine Registry and the Primary Care Clinical History. The 2011 deprivation index of the Spanish Society of Epidemiology is used as a socioeconomic indicator. Factors related to vaccination against mpox are analysed and a conditional logistic regression model is fitted.

Results: 6690 people were registered for PrEP. The average age was 37.7 years, 98.8% were men and 25.1% were foreigners. 39.9% had received vaccination against mpox, 47.6% had vaccination against hepatitis A, 32.8% vaccination against hepatitis B, 53.3% vaccination against COVID-19 and 24.3% vaccination against a complaint. The variables associated with mpox vaccination were age, country of birth, influenza vaccination, hepatitis A vaccination, COVID-19 vaccination, and deprivation index.

Conclusions: Men who had sex with men (MSM) on PrEP treatment, young adults, born in Spain, with a history of vaccination against influenza, hepatitis A and COVID-19 have a greater probability of vaccination against mpox. The proportion of vaccinated subjects decreases as the deprivation index increases (as socioeconomic level decreases).