Combining Top-Down and Bottom-Up: An Open Microfluidic Microtumor Model for Investigating Tumor Cell-ECM Interaction and Anti-Metastasis (Small 9/2025)
Chao Li, Jiayi Li, Zach Argall-Knapp, Nathan W. Hendrikse, Mehtab A. Farooqui, Bella Raykowski, Anna King, Serratt Nong, Yingguang Liu
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引用次数: 0
Abstract
Microtumor Model
By leveraging an exclusive liquid repellency (ELR)-underoil open microfluidic system (UOMS), an open microfluidics-based microtumor model for studying tumor cell migration in an in vivo-like confined space and interaction with extracellular matrix was developed. The UOMS microtumor model was tested with the anti-metastatic effect of incyclinide, showing the potential as an ex vivo platform for micrometastasis study and anti-metastasis drug screening. More in article number 2402499, Chao Li, Yingguang Liu, and co-workers.
期刊介绍：
Small serves as an exceptional platform for both experimental and theoretical studies in fundamental and applied interdisciplinary research at the nano- and microscale. The journal offers a compelling mix of peer-reviewed Research Articles, Reviews, Perspectives, and Comments.
With a remarkable 2022 Journal Impact Factor of 13.3 (Journal Citation Reports from Clarivate Analytics, 2023), Small remains among the top multidisciplinary journals, covering a wide range of topics at the interface of materials science, chemistry, physics, engineering, medicine, and biology.
Small's readership includes biochemists, biologists, biomedical scientists, chemists, engineers, information technologists, materials scientists, physicists, and theoreticians alike.
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