{"title":"DBU-promoted cascade phosphorylation/cyclization for the synthesis of phosphorylated 3-aminoindoles†","authors":"Dong-Ping Xu , Fei Huang , Li-Zhen Jin , Meng-Ya Huang , Wu Zhang","doi":"10.1039/d5cc00224a","DOIUrl":null,"url":null,"abstract":"<div><div>A novel strategy of cascade phosphorylation cyclization of 2-isocyanobenzonitrile with phosphine oxide <em>via</em> a DBU-promoted process has been developed. A series of phosphorylated 3-aminoindoles were constructed by forming C–C, C–P and N–P bonds and an amino group in one pot. A plausible reaction mechanism has been proposed based on step-by-step control experiments and <sup>31</sup>P NMR analysis.</div></div>","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"61 25","pages":"Pages 4816-4819"},"PeriodicalIF":4.2000,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Communications","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1359734525003957","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
A novel strategy of cascade phosphorylation cyclization of 2-isocyanobenzonitrile with phosphine oxide via a DBU-promoted process has been developed. A series of phosphorylated 3-aminoindoles were constructed by forming C–C, C–P and N–P bonds and an amino group in one pot. A plausible reaction mechanism has been proposed based on step-by-step control experiments and 31P NMR analysis.
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