{"title":"DBU-promoted cascade phosphorylation/cyclization for the synthesis of phosphorylated 3-aminoindoles†","authors":"Dong-Ping Xu, Fei Huang, Li-Zhen Jin, Meng-Ya Huang and Wu Zhang","doi":"10.1039/D5CC00224A","DOIUrl":null,"url":null,"abstract":"<p >A novel strategy of cascade phosphorylation cyclization of 2-isocyanobenzonitrile with phosphine oxide <em>via</em> a DBU-promoted process has been developed. A series of phosphorylated 3-aminoindoles were constructed by forming C–C, C–P and N–P bonds and an amino group in one pot. A plausible reaction mechanism has been proposed based on step-by-step control experiments and <small><sup>31</sup></small>P NMR analysis.</p>","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":" 25","pages":" 4816-4819"},"PeriodicalIF":4.3000,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Communications","FirstCategoryId":"92","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2025/cc/d5cc00224a","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
A novel strategy of cascade phosphorylation cyclization of 2-isocyanobenzonitrile with phosphine oxide via a DBU-promoted process has been developed. A series of phosphorylated 3-aminoindoles were constructed by forming C–C, C–P and N–P bonds and an amino group in one pot. A plausible reaction mechanism has been proposed based on step-by-step control experiments and 31P NMR analysis.
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