Early BMI Change, Cognitive Decline, and CSF AD Biomarkers Alterations in Parkinson's Disease.

IF 4.4 2区医学 Q1 CLINICAL NEUROLOGY Annals of Clinical and Translational Neurology Pub Date : 2025-03-03 DOI:10.1002/acn3.70018

Rui Zhong, Kezhong Zhang

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Abstract

Objective: To examine the relationship of early BMI change with subsequent cognitive decline, CSF AD biomarkers alterations, and progression to dementia in patients with PD.

Methods: Study data were prospectively collected from the PPMI cohort. Weight/height data at enrollment and second-year clinical visit were utilized to calculate BMI change. Cognitive tests and CSF AD biomarkers were measured at enrollment and each visit during the 5-year follow-up. Generalized linear mixed analyses were employed to identify the impact of BMI change on the deterioration of cognitive performance and CSF AD biomarkers alterations. Cox regression analyses were employed to assess the relationship of BMI change with dementia conversion.

Results: BMI loss predicted a more rapid deterioration in global cognitive performance over time. Regarding specific cognitive domains, participants in the BMI loss group experienced a significantly more rapid decline in verbal episodic memory, language, and processing speed/attention compared with those in the stable BMI group. Additionally, patients in the BMI gain group showed a slower decline in verbal episodic memory than those in the stable BMI group. BMI loss predicted a more rapid longitudinal decrease of CSF Aβ42 over time. BMI change was not associated with the risk of progression to dementia.

Conclusions: Early BMI loss is a risk factor for faster decline in cognition and longitudinal decrease of CSF Aβ42. These findings emphasize the need to monitor early BMI change in PD patients. Attention to early BMI change may help identify those at greater risk of cognitive decline.

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目的研究帕金森病患者早期体重指数变化与认知能力下降、脑脊液AD生物标志物变化及痴呆进展之间的关系：研究数据是从 PPMI 队列中收集的前瞻性数据。利用入组和第二年临床访视时的体重/身高数据计算BMI变化。认知测试和脑脊液AD生物标志物在入组和5年随访期间的每次就诊时进行测量。采用广义线性混合分析来确定 BMI 变化对认知能力恶化和 CSF AD 生物标志物变化的影响。Cox回归分析用于评估BMI变化与痴呆转换之间的关系：结果：随着时间的推移，体重指数的下降预示着整体认知能力会更快地恶化。在特定认知领域，BMI下降组的参与者与BMI稳定组的参与者相比，在言语外显记忆、语言和处理速度/注意力方面的下降速度明显更快。此外，与体重指数稳定组相比，体重指数增加组患者的言语外显记忆力下降速度较慢。随着时间的推移，BMI 下降预示着 CSF Aβ42 的纵向下降速度更快。BMI的变化与发展为痴呆症的风险无关：结论：早期体重指数下降是导致认知能力更快下降和脑脊液Aβ42纵向下降的风险因素。这些发现强调了监测帕金森病患者早期体重指数变化的必要性。关注早期BMI变化有助于识别认知能力下降风险较大的患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Clinical and Translational Neurology Medicine-Neurology (clinical)

CiteScore

9.10

自引率

1.90%

发文量

218

审稿时长

8 weeks

期刊介绍： Annals of Clinical and Translational Neurology is a peer-reviewed journal for rapid dissemination of high-quality research related to all areas of neurology. The journal publishes original research and scholarly reviews focused on the mechanisms and treatments of diseases of the nervous system; high-impact topics in neurologic education; and other topics of interest to the clinical neuroscience community.