Morphometric variation in central airways of ten different human lung.

Abstract

The prevailing scarcity of accurate lung models poses challenges to predicting airborne particle deposition across genders. The present work demonstrates the details of the geometrical specifications of central airways for ten healthy humans (male and female). The data were extracted from HRCT scan images with a minimum resolution of 1 mm. The images cover the trachea to all branches of the G6-G8 generations. The presented data include airway segment diameters, lengths, branching angles, and angles of inclination to gravity, in addition to their average and standard deviation. Our first goal in this study is to generate an average lung model exclusively for humans in laboratory and 1D numerical inhalation investigations. Thus, our primary emphasis in this work is to find the average suitable inclination angle in all generations of central airways for men and women by comparing the available data from previous studies. In the second part of the paper, we have also investigated the particle deposition efficiency in these ten models using the Mimetikos PreludiumTM software package. We compared the regional deposition between males and females and the available respiratory system models.