Evaluation of the Effect of Acute Elevated Intraocular Pressure on Retinal and Choroidal Microvasculature in Diabetic Rats.

IF 2.8 3区医学 Q3 ENDOCRINOLOGY & METABOLISM Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pub Date : 2025-02-26 eCollection Date: 2025-01-01 DOI:10.2147/DMSO.S493984

Yao Yao, Yanni Yan, Wenbin Wei, Qian Wang

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引用次数: 0

Abstract

Purpose: Understanding the dynamics of blood flow regulation in diabetic conditions is crucial for developing targeted interventions. This study aimed to investigate the impact of acute intraocular pressure (IOP) elevation on retinal and choroidal microvasculature in diabetic and control rats.

Methods: Male Sprague-Dawley rats were divided into two groups: diabetic and control. Acute IOP elevation was achieved through controlled perfusion pressure. Retinal and choroidal blood flow was measured using Swept-Source Optical Coherence Tomography Angiography (SS-OCT/OCTA).

Results: At baseline IOP levels, there were no statistically significant differences in perfusion area (PA) between the two groups in all regions of the retina and choroid. During acute IOP elevation, both diabetic and control rats experienced a significant reduction in retinal and choroidal blood flow perfusion. Diabetic rats manifested significantly higher (P<0.05) alterations in PA across nearly all retinal regions compared to the control group, barring specific sub-regions of the outer ring. Concerning choroidal PA, the diabetic group exhibited a more pronounced alteration than the control group across the entire 6-mm region and certain sub-regions of the outer ring.

Conclusion: Our results demonstrate a clear association between diabetes and impaired choroidal vascular autoregulation during acute IOP elevation. The observed reduction in retinal and choroidal microvasculature in diabetic rats points towards a compromised ability to maintain blood flow homeostasis under stress conditions.

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来源期刊

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

5.90

自引率

6.10%

发文量

431

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed, open access, online journal. The journal is committed to the rapid publication of the latest laboratory and clinical findings in the fields of diabetes, metabolic syndrome and obesity research. Original research, review, case reports, hypothesis formation, expert opinion and commentaries are all considered for publication.