Evaluation of the Effect of Acute Elevated Intraocular Pressure on Retinal and Choroidal Microvasculature in Diabetic Rats.

IF 3 3区医学 Q3 ENDOCRINOLOGY & METABOLISM Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pub Date : 2025-02-26 eCollection Date: 2025-01-01 DOI:10.2147/DMSO.S493984

Yao Yao, Yanni Yan, Wenbin Wei, Qian Wang

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Abstract

Purpose: Understanding the dynamics of blood flow regulation in diabetic conditions is crucial for developing targeted interventions. This study aimed to investigate the impact of acute intraocular pressure (IOP) elevation on retinal and choroidal microvasculature in diabetic and control rats.

Methods: Male Sprague-Dawley rats were divided into two groups: diabetic and control. Acute IOP elevation was achieved through controlled perfusion pressure. Retinal and choroidal blood flow was measured using Swept-Source Optical Coherence Tomography Angiography (SS-OCT/OCTA).

Results: At baseline IOP levels, there were no statistically significant differences in perfusion area (PA) between the two groups in all regions of the retina and choroid. During acute IOP elevation, both diabetic and control rats experienced a significant reduction in retinal and choroidal blood flow perfusion. Diabetic rats manifested significantly higher (P<0.05) alterations in PA across nearly all retinal regions compared to the control group, barring specific sub-regions of the outer ring. Concerning choroidal PA, the diabetic group exhibited a more pronounced alteration than the control group across the entire 6-mm region and certain sub-regions of the outer ring.

Conclusion: Our results demonstrate a clear association between diabetes and impaired choroidal vascular autoregulation during acute IOP elevation. The observed reduction in retinal and choroidal microvasculature in diabetic rats points towards a compromised ability to maintain blood flow homeostasis under stress conditions.

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急性眼压升高对糖尿病大鼠视网膜和脉络膜微血管影响的评价。

目的：了解糖尿病患者血流调节的动态对制定有针对性的干预措施至关重要。本研究旨在探讨急性眼压升高对糖尿病大鼠视网膜和脉络膜微血管的影响。方法：雄性Sprague-Dawley大鼠分为糖尿病组和对照组。通过控制灌注压实现急性IOP升高。使用扫源光学相干断层扫描血管造影（SS-OCT/OCTA）测量视网膜和脉络膜血流量。结果：在基线IOP水平下，两组视网膜和脉络膜各区域的灌注面积（PA）差异无统计学意义。在急性IOP升高期间，糖尿病大鼠和对照组大鼠的视网膜和脉络膜血流灌注均显著减少。结论：我们的研究结果表明糖尿病与急性IOP升高期间脉络膜血管自动调节受损之间存在明显的关联。观察到糖尿病大鼠视网膜和脉络膜微血管的减少，表明在应激条件下维持血流稳态的能力受损。

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来源期刊

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

5.90

自引率

6.10%

发文量

431

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed, open access, online journal. The journal is committed to the rapid publication of the latest laboratory and clinical findings in the fields of diabetes, metabolic syndrome and obesity research. Original research, review, case reports, hypothesis formation, expert opinion and commentaries are all considered for publication.