Nanocellulose Extraction from Biomass Waste: Unlocking Sustainable Pathways for Biomedical Applications

IF 7.5 2区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Chemical record Pub Date : 2025-03-04 DOI:10.1002/tcr.202400249

Dr. Mehrdad Ghamari, Dr. Suvish, Prof. Dr. Chan Hwang See, Prof. Dr. Hongnian Yu, Dr. Thiyagarajan Anitha, Prof. Dr. V. T. Balamurugan, Dr. Sasireka Velusamy, Prof. Dr. David Hughes, Prof. Dr. Senthilarasu Sundaram

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Abstract

The escalating global waste crisis necessitates innovative solutions. This study investigates the sustainable production of nanocellulose from biomass waste and its biomedical applications. Cellulose-rich materials–including wood, textiles, agricultural residues, and food by-products–were systematically processed using alkaline, acid, and oxidative pretreatments to enhance fiber accessibility. Mechanical techniques, such as grinding and homogenization, combined with chemical methods like acid hydrolysis and 2,2,6,6-Tetramethylpiperidin-1-yl-oxyl (TEMPO) oxidation, were employed to successfully isolate nanocellulose. Post-treatment modifications, including surface coating and cross-linking, further tailored its properties for specific applications. The results demonstrated nanocellulose's biocompatibility, biodegradability, and functional versatility. In wound healing, it enhanced moisture management and exhibited antimicrobial properties. Its high surface area facilitated efficient drug loading and controlled release in drug delivery applications. Nanocellulose bioinks supported cell proliferation in 3D bioprinting for tissue engineering. Additional applications in biosensors and personal care products were also identified. This study advances sustainable materials science, aligning resource conservation with circular economy principles to address biomedical sector needs.

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从生物质废物中提取纳米纤维素：解锁生物医学应用的可持续途径。

不断升级的全球废物危机需要创新的解决方案。本研究探讨了生物质废弃物可持续生产纳米纤维素及其生物医学应用。富含纤维素的材料——包括木材、纺织品、农业残留物和食品副产品——采用碱性、酸性和氧化预处理进行系统处理，以提高纤维的可及性。采用研磨和均质等机械技术，结合酸水解和2,2,6,6-四甲基胡椒碱-1-基氧（TEMPO）氧化等化学方法，成功分离了纳米纤维素。后处理修改，包括表面涂层和交联，进一步定制其特定应用的性能。结果表明纳米纤维素具有生物相容性、生物可降解性和功能通用性。在伤口愈合中，它增强了水分管理并表现出抗菌特性。它的高表面积有利于有效的药物装载和药物释放控制应用。纳米纤维素生物墨水支持组织工程3D生物打印中的细胞增殖。还确定了生物传感器和个人护理产品的其他应用。这项研究推进了可持续材料科学，将资源保护与循环经济原则结合起来，以满足生物医学部门的需求。

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来源期刊

Chemical record 化学-化学综合

CiteScore

11.00

自引率

3.00%

发文量

188

审稿时长

>12 weeks

期刊介绍： The Chemical Record (TCR) is a "highlights" journal publishing timely and critical overviews of new developments at the cutting edge of chemistry of interest to a wide audience of chemists (2013 journal impact factor: 5.577). The scope of published reviews includes all areas related to physical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, polymer chemistry, materials chemistry, bioorganic chemistry, biochemistry, biotechnology and medicinal chemistry as well as interdisciplinary fields. TCR provides carefully selected highlight papers by leading researchers that introduce the author''s own experimental and theoretical results in a framework designed to establish perspectives with earlier and contemporary work and provide a critical review of the present state of the subject. The articles are intended to present concise evaluations of current trends in chemistry research to help chemists gain useful insights into fields outside their specialization and provide experts with summaries of recent key developments.