Radiographic Identification of Visceroptosis in Patients With Hypermobile Ehlers-Danlos Syndrome With Functional Gastrointestinal Symptoms Compared With Healthy Subjects.

IF 3 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Clinical and Translational Gastroenterology Pub Date : 2025-05-01 DOI:10.14309/ctg.0000000000000834

Yin Chan, Bianca W Chang, Amrit K Kamboj, Yaniv Raphael, Richard Sukov, Ali Rezaie

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Abstract

Introduction: Visceroptosis is a potential cause of gastrointestinal symptoms in hypermobile Ehlers-Danlos syndrome (hEDS).

Methods: We systematically examined the prolapse of abdominal organs below their natural supine position (visceroptosis) during the upright small bowel barium study in healthy and hEDS subjects with irritable bowel syndrome.

Results: Comparison of age- and sex-matched healthy (n = 20) and hEDS (n = 10) subjects did not show any significant difference in dynamic movement of the viscera. Subgroup analysis did not demonstrate any correlation between the degree of prolapse, clinical symptoms, and hypermobility clinical (Beighton) scores. The interobserver reliability for 3 of the 4 anatomic landmarks showed "moderate" or "good" correlation based on their interclass correlation coefficients.

Discussion: Patients with hEDS do not appear to have a significantly increased incidence of visceroptosis.

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伴有胃肠功能症状的多动性埃勒-丹洛斯综合征患者与健康人群内脏下垂的影像学鉴别

简介：内脏下垂是多动症患者胃肠道症状的一个潜在原因。方法：我们系统地检查了健康和患有肠易激综合征的hEDS患者在直立小肠钡餐检查时腹部器官在自然仰卧位以下的脱垂（内脏下垂）。结果：年龄和性别匹配的健康受试者（n=20）与hEDS受试者（n=10）相比，脏器动态运动无显著差异。亚组分析未显示脱垂程度、临床症状和多动症临床（Beighton）评分之间有任何相关性。基于类间相关系数，4个解剖标志中3个的观察者间信度显示出“中等”或“良好”的相关性。讨论：hEDS患者似乎没有明显增加内脏下垂的发生率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Translational Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

7.00

自引率

0.00%

发文量

114

审稿时长

16 weeks

期刊介绍： Clinical and Translational Gastroenterology (CTG), published on behalf of the American College of Gastroenterology (ACG), is a peer-reviewed open access online journal dedicated to innovative clinical work in the field of gastroenterology and hepatology. CTG hopes to fulfill an unmet need for clinicians and scientists by welcoming novel cohort studies, early-phase clinical trials, qualitative and quantitative epidemiologic research, hypothesis-generating research, studies of novel mechanisms and methodologies including public health interventions, and integration of approaches across organs and disciplines. CTG also welcomes hypothesis-generating small studies, methods papers, and translational research with clear applications to human physiology or disease. Colon and small bowel Endoscopy and novel diagnostics Esophagus Functional GI disorders Immunology of the GI tract Microbiology of the GI tract Inflammatory bowel disease Pancreas and biliary tract Liver Pathology Pediatrics Preventative medicine Nutrition/obesity Stomach.