{"title":"Prognostic factors and outcomes in pediatric acute myeloid leukemia: a comprehensive bibliometric analysis of global research trends.","authors":"Mingliang Rao, Wenna Luo, Caiju Luo, Baojing Wu, Tiantian Xu, Ziqian Wei, Haolan Deng, Kejing Li, Dunhua Zhou","doi":"10.3389/fonc.2025.1466818","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Pediatric AML prognosis research has advanced significantly, yet gaps in understanding genetic and molecular interactions persist. Despite improved outcomes, relapse/refractory cases and personalized treatment integration remain critical clinical challenges.</p><p><strong>Objective: </strong>To analyze the global research landscape on pediatric AML prognosis, highlight influential components and collaborations, and identify major potential research trends.</p><p><strong>Methods: </strong>Publications on pediatric AML prognosis research from 1999 to 2023 were retrieved from the Clarivate Analytics Web of Science Core Collection (WoSCC) database. Bibliometric analysis was conducted using CiteSpace and VOSviewer to identify leading countries, prominent institutions, high-impact journals, key research categories, influential authors, and emerging research topics.</p><p><strong>Results: </strong>The bibliometric analysis encompassed 924 publications, with St. Jude Children's Research Hospital emerging as the most prolific institution. The United States leads globally in terms of countries, institutions, journals, and authors. Todd A. Alonzo ranks highest in publication volume, while U. Creutzig leads in citations. The top research categories were Oncology, Hematology, and Pediatrics. Key research topics included genomics, transcriptomics, epigenomics, targeted therapies, immune therapy, and integrative diagnostic approaches.</p><p><strong>Conclusion: </strong>This bibliometric analysis highlights significant advancements in pediatric AML prognosis over the past 25 years, driven by the integration of genetic markers, immunological insights, transcriptomics, and epigenomics, which have collectively transformed risk stratification and treatment strategies. Overcoming challenges, such as discovering new therapeutic targets and enhancing treatment combinations, will depend on global collaboration and advanced technologies to propel the field forward.</p>","PeriodicalId":12482,"journal":{"name":"Frontiers in Oncology","volume":"15 ","pages":"1466818"},"PeriodicalIF":3.5000,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11873564/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Oncology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fonc.2025.1466818","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Pediatric AML prognosis research has advanced significantly, yet gaps in understanding genetic and molecular interactions persist. Despite improved outcomes, relapse/refractory cases and personalized treatment integration remain critical clinical challenges.
Objective: To analyze the global research landscape on pediatric AML prognosis, highlight influential components and collaborations, and identify major potential research trends.
Methods: Publications on pediatric AML prognosis research from 1999 to 2023 were retrieved from the Clarivate Analytics Web of Science Core Collection (WoSCC) database. Bibliometric analysis was conducted using CiteSpace and VOSviewer to identify leading countries, prominent institutions, high-impact journals, key research categories, influential authors, and emerging research topics.
Results: The bibliometric analysis encompassed 924 publications, with St. Jude Children's Research Hospital emerging as the most prolific institution. The United States leads globally in terms of countries, institutions, journals, and authors. Todd A. Alonzo ranks highest in publication volume, while U. Creutzig leads in citations. The top research categories were Oncology, Hematology, and Pediatrics. Key research topics included genomics, transcriptomics, epigenomics, targeted therapies, immune therapy, and integrative diagnostic approaches.
Conclusion: This bibliometric analysis highlights significant advancements in pediatric AML prognosis over the past 25 years, driven by the integration of genetic markers, immunological insights, transcriptomics, and epigenomics, which have collectively transformed risk stratification and treatment strategies. Overcoming challenges, such as discovering new therapeutic targets and enhancing treatment combinations, will depend on global collaboration and advanced technologies to propel the field forward.
背景：儿童AML预后研究取得了显著进展，但在理解遗传和分子相互作用方面仍然存在差距。尽管预后有所改善，但复发/难治性病例和个性化治疗整合仍然是关键的临床挑战。目的：分析全球儿童AML预后的研究现状，突出影响因素和合作，并确定主要的潜在研究趋势。方法：从Clarivate Analytics Web of Science Core Collection （WoSCC）数据库中检索1999年至2023年有关儿童AML预后研究的出版物。利用CiteSpace和VOSviewer进行文献计量分析，确定主要国家、知名机构、高影响力期刊、重点研究类别、有影响力的作者和新兴研究课题。结果：文献计量学分析包括924份出版物，其中St. Jude儿童研究医院成为最多产的机构。美国在国家、机构、期刊和作者方面都处于全球领先地位。Todd A. Alonzo在出版物数量上排名最高，而U. Creutzig在引用上排名第一。排名靠前的研究类别是肿瘤学、血液学和儿科。重点研究课题包括基因组学、转录组学、表观基因组学、靶向治疗、免疫治疗和综合诊断方法。结论：这项文献计量学分析强调了过去25年来儿科AML预后的重大进展，这是由遗传标记、免疫学见解、转录组学和表观基因组学的整合所推动的，它们共同改变了风险分层和治疗策略。克服挑战，如发现新的治疗靶点和加强治疗组合，将取决于全球合作和先进技术来推动该领域向前发展。
期刊介绍：
Cancer Imaging and Diagnosis is dedicated to the publication of results from clinical and research studies applied to cancer diagnosis and treatment. The section aims to publish studies from the entire field of cancer imaging: results from routine use of clinical imaging in both radiology and nuclear medicine, results from clinical trials, experimental molecular imaging in humans and small animals, research on new contrast agents in CT, MRI, ultrasound, publication of new technical applications and processing algorithms to improve the standardization of quantitative imaging and image guided interventions for the diagnosis and treatment of cancer.
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