Application of artificial intelligence in Alzheimer's disease: a bibliometric analysis.

Abstract

Background: Understanding how artificial intelligence (AI) is employed to predict, diagnose, and perform relevant analyses in Alzheimer's disease research is a rapidly evolving field. This study integrated and analyzed the relevant literature from the Science Citation Index (SCI) and Social Science Citation Index (SSCI) on the application of AI in Alzheimer's disease (AD), covering publications from 2004 to 2023.

Objective: This study aims to identify the key research hotspots and trends of the application of AI in AD over the past 20 years through a bibliometric analysis.

Methods: Using the Web of Science Core Collection database, we conducted a comprehensive visual analysis of literature on AI and AD published between January 1, 2004, and December 31, 2023. The study utilized Excel, Scimago Graphica, VOSviewer, and CiteSpace software to visualize trends in annual publications and the distribution of research by countries, institutions, journals, references, authors, and keywords related to this topic.

Results: A total of 2,316 papers were obtained through the research process, with a significant increase in publications observed since 2018, signaling notable growth in this field. The United States, China, and the United Kingdom made notable contributions to this research area. The University of London led in institutional productivity with 80 publications, followed by the University of California System with 74 publications. Regarding total publications, the Journal of Alzheimer's Disease was the most prolific while Neuroimage ranked as the most cited journal. Shen Dinggang was the top author in both total publications and average citations. Analysis of reference and keyword highlighted research hotspots, including the identification of various stages of AD, early diagnostic screening, risk prediction, and prediction of disease progression. The "task analysis" keyword emerged as a research frontier from 2021 to 2023.

Conclusion: Research on AI applications in AD holds significant potential for practical advancements, attracting increasing attention from scholars. Deep learning (DL) techniques have emerged as a key research focus for AD diagnosis. Future research will explore AI methods, particularly task analysis, emphasizing integrating multimodal data and utilizing deep neural networks. These approaches aim to identify emerging risk factors, such as environmental influences on AD onset, predict disease progression with high accuracy, and support the development of prevention strategies. Ultimately, AI-driven innovations will transform AD management from a progressive, incurable state to a more manageable and potentially reversible condition, thereby improving healthcare, rehabilitation, and long-term care solutions.