A Systematic Review of Anxiety and Depressive Symptoms Among Women Experiencing Vasomotor Symptoms Across Reproductive Stages in the US.

IF 2.6 4区医学 Q2 OBSTETRICS & GYNECOLOGY International Journal of Women's Health Pub Date : 2025-02-27 eCollection Date: 2025-01-01 DOI:10.2147/IJWH.S491640

Carolyn J Gibson, Mayank Ajmera, Fiona O'Sullivan, Aki Shiozawa, Greta Lozano-Ortega, Elizabeth C Badillo, Maanasa Venkataraman, Shayna Mancuso

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Abstract

Purpose: Vasomotor symptoms (VMS) due to menopause affect up to 80% of women and are associated with fatigue, depressive symptoms, and anxiety although the exact nature of these associations is not fully understood. This systematic review aimed to examine the existing evidence on the relationship between VMS, fatigue, depressive symptoms, and anxiety among women in any stage of reproductive aging in the United States.

Methods: A comprehensive search of MEDLINE and Embase databases was performed to identify observational studies (2010-2022) that reported on the target population. Exposure of interest was VMS; data related to the outcomes of interest (measures of fatigue, depressive symptoms, and/or anxiety) were extracted and analyzed descriptively.

Results: Twenty-six studies met the inclusion criteria, with 19 reporting on depressive symptom outcomes, 16 on anxiety outcomes, and none on fatigue. The mean age of women with VMS ranged from 41.3 to 62.0 years; 34.8% to 91.1% of women were premenopausal or in the late stage of reproductive aging, 0.6% to 61% were perimenopausal or in menopause transition, and 0% to 49% were postmenopausal. The most frequent comorbidities were hypertension and diabetes. Baseline depressive symptom rates ranged from 1.4% to 58%, with higher rates and more severe symptoms among women with more frequent and severe VMS. Anxiety rates at baseline ranged from 2.2% to 52%, with higher rates reported among women with frequent VMS. Anxiety levels varied, with the highest levels observed among women with sleep disturbances and severe hot flashes. In regression model analyses, VMS were associated with increased risk, duration, frequency, and severity of both depressive symptoms and anxiety.

Conclusion: VMS are strongly and consistently associated with depressive symptoms and anxiety, negatively affecting a woman's health beyond physical discomfort. There is a need to reduce this burden and improve quality of life for women with VMS.

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美国生殖阶段出现血管舒缩症状的女性焦虑和抑郁症状的系统回顾

目的：由更年期引起的血管舒缩症状（VMS）影响多达80%的女性，并与疲劳、抑郁症状和焦虑相关，尽管这些关联的确切性质尚不完全清楚。本系统综述旨在研究美国处于生殖衰老任何阶段的女性VMS、疲劳、抑郁症状和焦虑之间关系的现有证据。方法：对MEDLINE和Embase数据库进行全面检索，以确定报告目标人群的观察性研究（2010-2022）。兴趣暴露为VMS；提取与感兴趣的结果相关的数据（疲劳、抑郁症状和/或焦虑的测量）并进行描述性分析。结果：26项研究符合纳入标准，其中19项报告抑郁症状结果，16项报告焦虑结果，没有报告疲劳。女性VMS的平均年龄为41.3 ~ 62.0岁；34.8% ~ 91.1%的妇女处于绝经前或生殖老龄化晚期，0.6% ~ 61%的妇女处于围绝经期或绝经过渡期，0% ~ 49%的妇女处于绝经后。最常见的合并症是高血压和糖尿病。基线抑郁症状率从1.4%到58%不等，VMS更频繁和更严重的女性发病率更高，症状更严重。基线焦虑率从2.2%到52%不等，频繁发生VMS的女性报告的焦虑率更高。焦虑程度各不相同，在睡眠障碍和严重潮热的女性中，焦虑程度最高。在回归模型分析中，VMS与抑郁症状和焦虑的风险、持续时间、频率和严重程度增加有关。结论：VMS与抑郁症状和焦虑密切相关，除了身体不适外，还会对女性健康产生负面影响。有必要减轻这种负担，提高VMS妇女的生活质量。

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来源期刊

International Journal of Women's Health OBSTETRICS & GYNECOLOGY-

CiteScore

3.70

自引率

0.00%

发文量

194

审稿时长

16 weeks

期刊介绍： International Journal of Women''s Health is an international, peer-reviewed, open access, online journal. Publishing original research, reports, editorials, reviews and commentaries on all aspects of women''s healthcare including gynecology, obstetrics, and breast cancer. Subject areas include: Chronic conditions including cancers of various organs specific and not specific to women Migraine, headaches, arthritis, osteoporosis Endocrine and autoimmune syndromes - asthma, multiple sclerosis, lupus, diabetes Sexual and reproductive health including fertility patterns and emerging technologies to address infertility Infectious disease with chronic sequelae including HIV/AIDS, HPV, PID, and other STDs Psychological and psychosocial conditions - depression across the life span, substance abuse, domestic violence Health maintenance among aging females - factors affecting the quality of life including physical, social and mental issues Avenues for health promotion and disease prevention across the life span Male vs female incidence comparisons for conditions that affect both genders.