Development of an affine transformation based treatment control system for accelerator based boron neutron capture therapy.

Abstract

This study developed and validated an adaptive treatment control system based on affine transformation for accelerator-based boron neutron capture therapy. Accelerator-based boron neutron capture therapy is a form of targeted radiotherapy that uses boron-10 to label tumor cells. When these boron-rich cells interact with neutrons, they produce high-linear energy transfer alpha particles and lithium-7 particles, effectively destroying the tumor cells with precision. The newly developed treatment control system integrates real-time stereoscopic x-ray imaging technology, enabling dynamic adjustments to the treatment plan by continuously monitoring changes in tumors and surrounding tissues. To optimize treatment accuracy, the system employs an affine transformation algorithm, ensuring precise dose delivery and accurate patient positioning. Positioning test results demonstrate that the system excels in its core functionality of ensuring patient positioning accuracy, significantly improving treatment adaptability while minimizing damage to healthy tissues. In addition, the study introduces the accelerator-based boron neutron capture therapy device independently designed and constructed by Lanzhou University. This includes a detailed description of the system's architecture, algorithms, and the principles behind its safety interlock functions. Spatial positioning tests of the device confirmed its high overall positioning accuracy, validating the system's reliability and highlighting its potential for broader applications in cancer treatment.