Temporomandibular Dysfunction and Sleep Apnea in Dutch Adults With Osteogenesis Imperfecta.

Abstract

Objective: This study investigated self-reported symptoms of temporomandibular disorders, mandibular functional impairment, and obstructive sleep apnea among Dutch adults with Osteogenesis Imperfecta.

Materials and methods: A cross-sectional online survey was distributed among Dutch adults with Osteogenesis Imperfecta. Possible risk factors for self-reported temporomandibular disorders (3Q/TMD; DC/TMD), mandibular impairments (Mandibular Function Impairment Questionnaire), and obstructive sleep apnea (STOP-Bang) were explored using univariate and multiple regression analyses.

Results: 31% of 155 respondents reported temporomandibular disorder symptoms and 40.0% and 5.2% moderate and severe mandibular function impairment, respectively. Intermediate and severe risk for obstructive sleep apnea were reported by 16.1% and 14.8%, respectively. Female gender and Osteogenesis Imperfecta type III were independently associated with the presence of self-reported temporomandibular disorders. Osteogenesis Imperfecta type III, missing teeth, and self-reported temporomandibular disorders were independently associated with impaired mandibular function. Higher age, male gender, and bisphonate use were independently associated with a higher risk for positive screening for obstructive sleep apnea.

Conclusions: A substantial proportion of Dutch adults with Osteogenesis Imperfecta reported symptoms indicative of temporomandibular disorders, mandibular function impairment, and higher risk for obstructive sleep apnea. Especially Osteogenesis Imperfecta type III patients are at risk for self-reported temporomandibular disorders and hampered mandibular function.