Copper-catalyzed chemoselective C–H functionalization/dearomatization sequence: direct access to indole-based spirocyclic scaffolds†

IF 4.2 2区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Chemical Communications Pub Date : 2025-03-12 DOI:10.1039/d5cc00594a
Yuting Zhao , Xin Ji , Yuanjing Xiao , Xingxing Wu , Lu Liu
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Abstract

Herein, a copper-catalyzed intermolecular [4+1] spiroannulation of indoles with alkynyldiazoketones affording various indole-based spirocyclic molecules via a chemoselective C–H functionalization/dearomatization sequence was developed.

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铜催化的化学选择性 C-H 功能化/脱芳烃序列:直接获得吲哚基螺环支架
本文通过化学选择性C-H功能化/脱芳化序列,建立了铜催化吲哚与炔基重氮酮的分子间[4+1]旋环反应。在这个方案中,各种吲哚基的螺旋环分子可以得到良好的产率,具有优异的化学选择性和中等至良好的非对映选择性。
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来源期刊
Chemical Communications
Chemical Communications 化学-化学综合
CiteScore
8.60
自引率
4.10%
发文量
2705
审稿时长
1.4 months
期刊介绍: ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.
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