Preparation and characteristics of double-layer hydrogel-nanofiber FSG-(MgONRs/PCL/PVP) antibacterial membranes by electrospinning technology

Abstract

In order to effectively promote wound healing, endowing wound dressings with antibacterial function is a future challenge in this field. Nanometer magnesium oxide antibacterial agents are suitable for loading on wound dressing substrates because of its safety, large specific surface area and non-drug resistance. In this study, the double-layer hydrogel-nanofiber FSG-(MgONRs/PCL/PVP) antibacterial membranes used for wound dressing were prepared using PCL/PVP (CV) as nanofiber substrates, fish skin gelatin (FSG) as scaffolds and MgO nanorods (MgONRs) with positive charge as antibacterial agents by electrospinning technology. Characterizations such as scanning electron microscopy (SEM), transmission electron microscope (TEM), attenuated total reflection fourier transform infrared spectroscopy (ATR-FTIR), X-ray diffraction (XRD), thermogravimetric analysis (TGA) and energy dispersive X-ray spectrometer (EDS) indicated that MgONRs were physically and evenly loaded on the membranes, and the NRCV-2.5 with positive charge were smooth and homogeneous with an average diameter of 339.6 ± 135.7 nm. In addition, antibacterial and water absorption tests indicate that antibacterial rate of the NSCV-2.5 against Escherichia coli (E. coli) is 100 %, and the water absorption rate of the NSCV-2.5 reaches 413 g/g, which has great development potential in the field of wound dressing with antibacterial property and water absorption.