Progress of porous tantalum surface-modified biomaterial coatings in bone tissue engineering

IF 4.5 3区医学 Q2 ENGINEERING, BIOMEDICAL Journal of Materials Science: Materials in Medicine Pub Date : 2025-03-05 DOI:10.1007/s10856-025-06871-w

Aiguo Liu, Chenxu Wang, Ziwen Zhao, Rui Zhu, Shuang Deng, Sitong Zhang, Farnaz Ghorbani, Ting Ying, Chengqing Yi, Dejian Li

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Abstract

Tantalum (Ta) metal has emerged as a prominent material within the realm of bone tissue engineering, owing to its favorable biocompatibility, commendable mechanical attributes, and notable biological properties such as osteoconductivity, osteoinductivity, and angiogenic potential. However, as clinical applications have expanded, Ta implants have unveiled a spectrum of limitations. Consequently, porous tantalum (PTa) has garnered escalating interest, attributable to its unique microstructural attributes, tunable mechanical characteristics, and inherent biocompatibility. Various methodologies have been proposed to modify the surface of PTa, with the aim of accelerating and enhancing osseous integration while fostering more robust osseointegration. Strategic surface modifications have the potential to augment the inherent advantages of PTa, thereby offering diverse avenues for exploration within the realm of surface effects on PTa. This review elucidates the ongoing research endeavors concerning diverse biomaterial coatings applied to PTa surfaces in the context of bone tissue engineering.

Graphical Abstract

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多孔钽表面改性生物材料涂层在骨组织工程中的研究进展

钽（Ta）金属由于其良好的生物相容性、优良的力学特性和显著的生物特性，如骨导电性、骨诱导性和血管生成潜能，已成为骨组织工程领域的重要材料。然而，随着临床应用的扩大，Ta植入物暴露出一系列的局限性。因此，多孔钽（PTa）由于其独特的微观结构属性、可调的机械特性和固有的生物相容性而引起了越来越多的兴趣。已经提出了各种方法来修饰PTa表面，目的是加速和增强骨整合，同时促进更强健的骨整合。战略性表面修饰有可能增强PTa的固有优势，从而为探索表面对PTa的影响领域提供了多种途径。本文综述了骨组织工程中应用于PTa表面的各种生物材料涂层的研究进展。图形抽象

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来源期刊

Journal of Materials Science: Materials in Medicine 工程技术-材料科学：生物材料

CiteScore

8.00

自引率

0.00%

发文量

审稿时长

3.5 months

期刊介绍： The Journal of Materials Science: Materials in Medicine publishes refereed papers providing significant progress in the application of biomaterials and tissue engineering constructs as medical or dental implants, prostheses and devices. Coverage spans a wide range of topics from basic science to clinical applications, around the theme of materials in medicine and dentistry. The central element is the development of synthetic and natural materials used in orthopaedic, maxillofacial, cardiovascular, neurological, ophthalmic and dental applications. Special biomedical topics include biomaterial synthesis and characterisation, biocompatibility studies, nanomedicine, tissue engineering constructs and cell substrates, regenerative medicine, computer modelling and other advanced experimental methodologies.