Optimal bimetallic Au@Ag nanocuboids-based SERS sensor for label-free ultrasensitive detection of florfenicol residue in eggs

IF 5.3 2区化学 Q1 CHEMISTRY, ANALYTICAL Microchimica Acta Pub Date : 2025-03-05 DOI:10.1007/s00604-025-07076-2

Wei Wu, En Han, Lixin Ma, Ruiyun Zhou, Chen Wang, Junwen Bai, Jianrong Cai

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Abstract

A label-free surface-enhanced Raman scattering (SERS) sensor using optimal bimetallic Au@Ag nanocuboids (Au@Ag NCs) was developed for ultrasensitive detection of florfenicol residue in eggs. The Raman characteristic peaks of florfenicol detection were identified at 1145 cm⁻¹ and 1595 cm⁻¹ which were consistent with the theoretical Raman spectrum of florfenicol calculated by density functional theory. The Au@Ag NCs were optimized by changing the aspect ratio of Au nanorods and the thickness of Ag nanocuboids, achieving an enhancement factor of 1.69 × 10⁶ for SERS signals. Under optimal conditions, the label-free SERS sensor demonstrated a broad linear range of 0.01 mg/kg to 100 mg/kg for florfenicol in real sample. The limit of detection of florfenicol in eggs was as low as 0.0410 μg/kg, and the recovery was 94.83% ~ 108.24%. Therefore, this label-free SERS sensor offers a rapid and sensitive approach for the trace detection of florfenicol residues in food safety monitoring.

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基于双金属 Au@Ag 纳米立方体的最佳 SERS 传感器，用于无标记超灵敏检测鸡蛋中的氟苯尼考残留量

建立了一种无标记表面增强拉曼散射（SERS）传感器，该传感器采用最优双金属Au@Ag纳米椭球体（Au@Ag NCs），用于鸡蛋中氟苯尼考残留的超灵敏检测。氟苯尼考检测的拉曼特征峰位于1145 cm−1和1595 cm−1，与密度泛函理论计算的氟苯尼考理论拉曼光谱一致。通过改变金纳米棒的长宽比和银纳米立方体的厚度对Au@Ag纳米棒进行优化，SERS信号的增强因子达到1.69 × 106。在最佳条件下，无标记SERS传感器对实际样品中的氟苯尼考具有0.01 mg/kg ~ 100 mg/kg的宽线性范围。鸡蛋中氟苯尼考的检出限低至0.0410 μg/kg，回收率为94.83% ~ 108.24%。因此，该无标签SERS传感器为食品安全监测中氟苯尼考残留的痕量检测提供了一种快速、灵敏的方法。图形抽象

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文献相关原料

公司名称

产品信息

麦克林

Hexadecyl trimethyl ammonium bromide

麦克林

Florfenicol

麦克林

Hexadecyl trimethyl ammonium bromide

麦克林

Florfenicol

阿拉丁

ethyl acetate

阿拉丁

Hexadecyl trimethyl ammonium chloride

来源期刊

Microchimica Acta 化学-分析化学

CiteScore

9.80

自引率

5.30%

发文量

410

审稿时长

2.7 months

期刊介绍： As a peer-reviewed journal for analytical sciences and technologies on the micro- and nanoscale, Microchimica Acta has established itself as a premier forum for truly novel approaches in chemical and biochemical analysis. Coverage includes methods and devices that provide expedient solutions to the most contemporary demands in this area. Examples are point-of-care technologies, wearable (bio)sensors, in-vivo-monitoring, micro/nanomotors and materials based on synthetic biology as well as biomedical imaging and targeting.